Neurology News

SARS-CoV-2 can cause neurological complications, including neuroinflammation. This review highlights the use of [18F]DPA-714, a TSPO-specific radioligand, in PET-CT imaging to detect microglial activation in post-COVID-19 patients. Elevated [18F]DPA-714 uptake has been linked to symptoms like fatigue, cognitive issues, and mood changes. The compound aids in monitoring neuroinflammation progression and evaluating treatment responses. Challenges include TSPO genetic variability and the need for standardized imaging protocols. Overall, [18F]DPA-714 is a promising tool for research and personalized care in post-COVID neuroinflammation.

Myasthenia gravis is a neuromuscular disease typically associated with acetylcholine receptor (AChR) autoantibodies. However, in AChR-negative cases, autoantibodies against muscle-specific receptor tyrosine kinase (MuSK) may be present. Given the rarity of MuSK autoantibodies, there is limited information on their development and significance as biomarkers of disease activity. 

Chronic subdural hematoma (cSDH) is a common neurosurgical condition with high recurrence rates, particularly in elderly patients. The pathophysiology involves complex mechanisms of angiogenesis, fibrinolysis, and inflammation, leading to progressive hemorrhage and fluid accumulation.