Neurology News

A new study explores glymphatic system dysfunction in children with pediatric acquired demyelinating syndromes (PADS), highlighting a potential but under-recognised mechanism in neurological disease. While disruptions to the brain’s waste clearance system have been identified in adults, their role in paediatric cases has remained largely unclear.

This study explores the neurological mechanisms behind “brain fog” and other cognitive symptoms associated with Long COVID by analysing brain imaging and blood biomarkers in affected patients. Using MRI, cerebral blood flow imaging, and a range of neuropsychological tests, researchers identified associations between cognitive performance, anxiety and depression scores, and changes in blood flow in specific brain regions, particularly the occipital and parietal lobes. 

This review highlights how GBM exploits mechanisms such as MHC downregulation, immunosuppressive cytokine secretion, metabolic reprogramming, and recruitment of Tregs and myeloid-derived suppressor cells, reinforced by tumor heterogeneity and the blood–tumor barrier. 

Up to half of patients with large vessel occlusion (LVO) stroke experience futile recanalisation (FR) despite successful mechanical thrombectomy (MT). In a retrospective analysis of the MR CLEAN cohort (n=461), predictors of treatment response, vessel recanalisation, and FR were examined.

The full article explores how patient characteristics influence both technical and clinical success after thrombectomy.