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World Neurology

  • Early Endeavors to Build a CT Scan: The Ukraine Pioneers 8
    By Peter J. Koehler

    Some years ago, I presented a lecture on the history of CT and MR at the History of Neurology course of the American Academy of Neurology (2018). Soon after the invention of X-rays by Wilhelm Conrad Röntgen (1845-1923) in 1895, two steps needed to be made to improve brain imaging, notably the introduction of contrast enhancement and the production of 3D images.
  • American Epilepsy Society Announces Position Statement on Valproate Use in Women of Childbearing Potential ⧉

    The American Epilepsy Society (AES) president, R. Edward Hogan, MD, recently shared important information about the serious risks associated with use of valproate (valproic acid, divalproex) by women of childbearing potential, as highlighted in the updated AES Position Statement on the Use of Valproate by Women of Childbearing Potential.


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Journal of the Neurological Sciences

  • Timing stroke: A review on stroke pathophysiology and its influence over time on diffusion measures ⧉

    REVIEW ARTICLE | VOLUME 441 ⧉, 120377, OCTOBER 15, 2022

    Diffusion imaging (DWI) is considered an optimal technique to detect hyperacute cerebral ischemia and has thus enriched the clinical management of patients with suspected stroke. Researchers have taken this technique beyond with Diffusion Tensor Imaging (DTI)-extracted measures, which have been proposed as biomarkers of stroke progression. 


    We present here a narrative review on the different pathophysiological events underlying stroke from onset until late subacute stages and its relation to different brain edema forms.




  • Transient global amnesia. What's in a name? ⧉

    EDITORIAL | VOLUME 441, 120348, OCTOBER 15, 2022

    Over 3 decades ago, before MRI scanning was readily availble, I identified rather simple criteria for the diagnosis of Transient Global Amnesia (TGA) in a letter to the editor. (1) The attack onset should have been witnessed. (2) Dysfunction during the attack should have been limited to repetitive queries and amnesia. (3) There should have been no other major neurologic signs or symptoms. (4) The memory loss should have been transient, usually lasting hours or up to one day. Before then I had reviewed >500 published cases of TGA for the Handbook of Neurology and seen many patients with amnesia. 


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eNeurologicalSci (eNS)


  • Motor cortical plasticity and its correlation with motor symptoms in Parkinson's disease ⧉

    VOLUME 29, DECEMBER 2022, 100422

    The relationship between abnormal cortical plasticity and parkinsonian symptoms remains unclear in Parkinson's disease (PD).

    We studied the relationship between their symptoms and degree of Long-term potentiation (LTP)-like effects induced by quadripulse magnetic stimulation (QPS) over the primary motor cortex, which has a small inter-individual variability in humans.

    Our results suggest that motor cortical plasticity relate with mechanisms underlying bradykinesia and rigidity in the upper limb muscles. LTP induced by QPS may be used as an objective marker of parkinsonian symptoms.

  • Discussing brain magnetic resonance imaging results for neonates with hypoxic-ischemic encephalopathy treated with hypothermia: A challenge for clinicians and parents⧉

    VOLUME 29, DECEMBER 2022, 100424

    Clinicians use brain magnetic resonance imaging (MRI) to discuss neurodevelopmental prognosis with parents of neonates with hypoxic-ischemic encephalopathy (HIE) treated with therapeutic hypothermia (TH).

    This study investigates how clinicians and parents discuss these MRI results in the context of HIE and TH and how these discussions could be facilitated and more meaningful for parents.

    Discussing brain MRI results for neonates with HIE treated with TH are challenging tasks for clinicians and daunting moments for parents.


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