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By Aussan Al-Athwari, MD
The first Aden International Neurology Conference (ANC) brought together over 400 researchers, physicians, and experts in neurology, neurosurgery, internal medicine, radiology, psychiatry, and pediatrics to discuss updates in the field of neurology at the Crown Resort in Aden, Yemen.
The conference, which was held Dec. 18-19, 2024, was organized by the Aden Neurology Advisory Board (ANAB). Prof. Riadh Gouider, co-chair of the World Federation of Neurology (WFN) Education Committee, attended the opening ceremony and presented a report on the latest guidelines from the Middle East North Africa Committee for Treatment and Research in Multiple Sclerosis (MENACTRIMS)...
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By Peter J. Koehler
English playwright and poet William Shakespeare (1564-1616, see Figure 1) was born in Stratford-upon-Avon and is known as the "Bard of Avon." He wrote a vast body of work that includes no fewer than 39 plays and 154 sonnets. He married 26-year-old Anne Hathaway (1556-1623) in 1582, when he was 18 years old. They had three children, of whom the oldest, Susanna (1583-1649) married a local physician named John Hall (1575-1635). Hall studied at Queen's College Cambridge (BA 1593, MA 1597). However, he had no English medical degree and probably received medical training on the continent. This was possibly in France, as he was "a traveler acquainted with the French tongue."
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Jan-Hendrik Stahl, Max Konle, Markus Kowarik, Evelyn Dubois, Marcel Armbruster, Benedict Kleiser, Alexander Grimm, Pascal Martin, Justus Marquetand
Journal of the Neurological Sciences. 2025 May 15;472:123449.
Myasthenia gravis is a neuromuscular disease typically associated with acetylcholine receptor (AChR) autoantibodies. However, in AChR-negative cases, autoantibodies against muscle-specific receptor tyrosine kinase (MuSK) may be present. Given the rarity of MuSK autoantibodies, there is limited information on their development and significance as biomarkers of disease activity.
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Mohamed Elfil, Hazem S. Ghaith, Ahmed Elmashad, Zaid Najdawi, Mohammad Aladawi, Amro Elrefaei, Vishad Sukul, Merritt Kinon, Uchenna Okafo, John V. Wainwright, Pankajavalli Ramakrishnan, Elie Dancour, Eris Spirollari, Gurmeen Kaur, Stephan Mayer, Chirag D Gandhi, Fawaz Al-Mufti
Journal of the Neurological Sciences. 2025 Mar 21:123469.
Chronic subdural hematoma (cSDH) is a common and potentially serious condition where blood builds up between the brain and its outer covering, often affecting older adults. Traditional treatment usually involves surgical drainage, but recurrence and mortality rates remain high. This study reviewed data from four clinical trials involving 1,680 patients to assess whether an additional procedure—middle meningeal artery embolization (MMAE)—could improve outcomes when used alongside standard care.
The findings showed that adjunctive MMAE significantly reduced the risk of cSDH coming back by 44% and lowered mortality by 47%, without increasing major risks like stroke or serious complications. However, it didn't lead to better functional recovery compared to standard treatment alone. The results suggest MMAE is a promising supplement to usual care, but more research is needed to identify which patients benefit most and to refine how the procedure is performed.
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Zhou R, Sangam K, Cabrera A, AlMutawa F, Sivro A, Roy F, Silverman M, Sharma M, Budhram A.
Journal of the Neurological Sciences. 2025 Jan 3:123379.
To determine the positive predictive value (PPV) of CSF John Cunningham virus (JCV) quantitative PCR (qPCR) for progressive multifocal leukoencephalopathy (PML), and highlight neuroimaging findings reported to be suggestive of this disease.
We reviewed patients at London Health Sciences Centre with a positive CSF JCV qPCR result. Patients were classified as true-positive if they had a clinico-radiographic presentation compatible with PML and no more likely alternative diagnosis. The presence of suggestive neuroimaging findings was documented as supportive evidence of PML. The PPV of CSF JCV qPCR was calculated as the proportion of positive results that were classified as true-positives.
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Magiel E, Kozlov Y, Goldberg T, Dagan RL, Watad A, Gendelman O, Anis S.
Journal of the Neurological Sciences. 2024 Dec 30:123374.
Patients with connective tissue diseases (CTD) can have a wide range of neurological manifestations. Neurological complaints may be the presenting symptom of CTD. Therefore, screening for CTD using anti-nuclear antibodies (ANA) is a common practice. However, due to the abundance of positive ANA in a healthy population, interpretation of the results may be complex.
We retrospectively evaluated files of patients hospitalized for evaluation of neurological symptoms in Sheba Medical Center during the years 2007–2022. Data was collected regarding epidemiology, ANA status, and rheumatological diagnosis.
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Kaindl L, Hotz JF, Ferrari J.
eNeurologicalSci. 2025 Jun 1;39:100561.
Stroke represents a major public health problem, ranking as a leading cause of death and long-term disability worldwide. The goal of prevention strategies is to avoid the occurrence of stroke by educating both healthcare professionals and patients about the reduction of risk factors.
Despite increasing improvements in acute revascularization therapies, preventive measures remain more effective in decreasing the burden of stroke, as evidenced by the fact that over 75 % of strokes are first events. This paper attempts to provide a comprehensive approach by outlining risk factors and new therapeutic approaches. Understanding these is essential for healthcare providers and the general public to develop effective prevention strategies and ultimately reduce the overall incidence of stroke.
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Aka KC, Nancy ED, Muriel AT, Cedric AP, Delors OF, Arlette AD, David B, Axel TB, Constance YE, Christian T, Evelyne AD.
eNeurologicalSci. 2025 Apr 15:100566
This was a prospective cross-sectional study carried out during the 2022–2023 academic year at the Abidjan UFR of Medical Sciences. The study population consisted of all students in years 3ème to 6ème and hospital interns. The Schon questionnaire, transcribed using google form software, was sent to students using the "whatsapp" social network.
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Grisold W, Lewis SL.
eNeurologicalSci. 2025 Jan 5;38:100548
Congresses remain the main source of scientific meetings, combining science and education as well as personal interactions. Congresses are slowly returning to in-person meetings; however, some organizations, such as the World Federation of Neurology (WFN), adhere to the hybrid concept, both virtual and in-person.
To do this, we host the WFN World Congresses of Neurology (WCN), which reports the latest achievements and will remain hybrid (https://wcn-neurology.com); however, we think that two years between congresses is too long. For this reason, we introduced the World Federation of Neurology Digital Neurology Update (WNU)
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Crivelli L, Winkler A, Keller G, Beretta S, Calandri I, De Groote W, Fornari A, Frontera J, Kivipelto M, Lopez-Rocha AS, Mangialasche F.
eNeurologicalSci. 2024 Nov 21:100539
This systematic review analyzes the impact of COVID-19 on dementia patients' functional, cognitive, neuropsychiatric, and health related outcomes. It hypothesizes that dementia patients infected with SARS-CoV-2experience more pronounced deterioration compared to those who are uninfected.
Among 198 studies reviewed, only three met the criteria. Chen et al. (2023) identified higher mortality in SARS-CoV-2-infected dementia patients, while Merla et al. (2023) observed faster cognitive decline in infected individuals with increased hospital admissions. Additionally, Cascini et al. (2022) reported an increased risk of infection and significantly elevated mortality in dementia patients, highlighting comorbidities and antipsychotic medication use as key risk factors.
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Rocca WA.
eNeurologicalSci. 2024 Dec 3:100544.
The practice of modern neurology is based on research evidence. Research evidence is constructed by teams of investigators throughout the world, from Tokyo to Buenos Aires, from Sidney to Vancouver, from New York to Rome. These investigators use research methods and tools to design and conduct their studies. Neuroepidemiology is the science used to conduct clinical studies and population studies and to construct medical research evidence. Thus, neuroepidemiology is the architecture of medical research evidence. In particular, epidemiologic methods are used to describe the frequency and distribution of neurological diseases in human populations, to discover risk and protective factors, to study outcomes of diseases, and to measure the response to treatments.
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