Authors: Novarella F, Nicolella V, Fiorenza M, Falco F, Monteiro I, Corsini G, Ranucci D, Carotenuto A, Petracca M, Lanzillo R, Salvatore E.
Editor's Choice
Journal of the Neurological Sciences. REVIEW ARTICLE| 2025 Jun 2:123562.
DOI: doi.org/10.1016/j.jns.2025.123562
In elderly individuals with multiple sclerosis (MS), levels of plasma neurofilament light chain (pNfL)—a biomarker typically associated with MS disease activity—were not linked to MS-specific features such as disability, disease-modifying treatment, or cognitive test performance. However, elevated pNfL levels were associated with biological signs of amyloid accumulation, a hallmark of Alzheimer's disease.
This suggests that in older adults with MS, high pNfL may reflect age-related changes like Alzheimer-type pathology rather than MS progression itself. Notably, amyloid accumulation was also linked to memory impairment, reinforcing the idea that overlapping neurodegenerative processes may contribute to cognitive decline in this population.
Web design by Tribal Systems