JNS-cover.jpgJournal of Neurological Sciences

Vol 339 | No. 1-2 | 15 April 2014 | Pages 1-240


Article TitleAuthor(s)Pages

In memoriam of Professor Theodore L. Munsat (1930–2013): His outstanding legacy with the WFN

24 February 2014

Abstract: The World Federation of Neurology (WFN) lost an outstanding leader on November 22, 2013 with the death of Professor Theodore Leon Munsat ("Ted"), in Waltham, Massachusetts, USA. Professor Mu...

Marco T. Medina 1-2

VZV reactivation: A comorbid connection?

18 February 2014

Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus. Primary infection usually results in varicella (chickenpox), after which the virus becomes latent in ganglionic neurons along the entire...

Shilpa Buch 3-4

Recovery from rabies: A call to arms

06 March 2014

In the current issue, de Souza reports a survivor of rabies with severe neurological sequelae , presumably caused by infection with a dog rabies virus variant. Although previously well-documented, sur...

Alan C. Jackson 5-7


Article TitleAuthor(s)Pages

Survival from rabies encephalitis

03 March 2014

Abstract: Rabies is a major public health problem in Asia and Africa, with nearly 60,000 deaths every year, and represents a substantial economic burden. Neurologists frequently encounter atypical cas...

Aaron de Souza, Shampur Narayan Madhusudana 8-14

Cognitive effects of repetitive transcranial magnetic stimulation in patients with neurodegenerative diseases — Clinician's perspective

14 February 2014

Abstract: Repetitive transcranial magnetic stimulation (rTMS) represents a promising tool for studying and influencing cognition in people with neurodegenerative diseases. This procedure is noninvasiv...

Lubomira Anderkova, Irena Rektorova 15-25

HLA-DRB1*15:01 and Epstein–Barr virus in a multiple sclerosis patient with psoriasis, nasopharyngeal and breast cancers. Lessons for possible hidden links for autoimmunity and cancer

26 February 2014

Abstract: Background: Multiple sclerosis (MS) patients have a low general cancer risk and cases of neoplastic comorbidity are attributed by many researchers in chance, or therapeutical side-effects. H...

Maria Anagnostouli, Georgios Anagnostoulis, Serafeim Katsavos, Maria Panagiotou, Evangelia Kararizou, Panagiota Davaki 26-31

Original Articles

Article TitleAuthor(s)Pages

Varicella zoster virus (VZV) in cerebral arteries of subjects at high risk for VZV reactivation

20 February 2014

Abstract: With a decline in varicella zoster virus (VZV)-specific cell-mediated immunity, VZV can reactivate, infect cerebral arteries and cause stroke. Previous studies of cerebral arteries from subj...

Maria A. Nagel, Nelly Khmeleva, Alexander Choe, Jose Gutierrez, Don Gilden 32-34

Magnetic resonance spectroscopy findings as related to fatigue and cognitive performance in multiple sclerosis patients with mild disability

27 January 2014

Abstract: Background: The origin of fatigue in multiple sclerosis (MS) remains unclear. Magnetic resonance spectroscopy (MRS) provides an insight into metabolic properties of the brain. Objectives: Th...

Anna Pokryszko-Dragan, Joanna Bladowska, Anna Zimny, Krzysztof Slotwinski, Mieszko Zagrajek, Ewa Gruszka, Malgorzata Bilinska, Marek Sasiadek, Ryszard Podemski 35-40

Risk factors and acute ischemic stroke subtypes

31 January 2014

Abstract: Background: Acute ischemic stroke (AIS) is influenced by gender, age, and the brain site affected. Better characterization of AIS is necessary for improving guidelines, prevention, and desti...

Aliaksei Kisialiou, Rodolfo Grella, Albino Carrizzo, Giordana Pelone, Michelangelo Bartolo, Chiara Zucchella, Francesco Rozza, Giovanni Grillea, Claudio Colonnese, Luigi Formisano, Maria Lembo, Annibale A. Puca, Carmine Vecchione 41-46

Does measuring the median nerve at the carpal tunnel outlet improve ultrasound CTS diagnosis?

03 February 2014

Abstract: Introduction: Nerve conduction is often regarded as more sensitive than ultrasonography (US) for diagnosing carpal tunnel syndrome (CTS). The diagnostic value of US derives from median nerve...

P.R. Paliwal, A.K. Therimadasamy, Y.C. Chan, E.P. Wilder-Smith 47-51

Antibodies against interferon-beta in neuromyelitis optica patients

31 January 2014

Abstract: Neuromyelitis optica (NMO) is an antibody-mediated autoimmune inflammatory disease of the CNS. A poor response to treatment with recombinant interferon beta (IFN-ß) in NMO patients has been ...

Nasrin Asgari, Kirsten Ohm Kyvik, Troels Steenstrup, Egon Stenager, Soeren Thue Lillevang 52-56

A 10-year follow-up of a population-based study of people with multiple sclerosis in Stockholm, Sweden: Changes in health-related quality of life and the value of different factors in predicting health-related quality of life

03 February 2014

Abstract: Background: Health-related quality of life (HRQL) in people with multiple sclerosis (PwMS) is negatively affected compared to that of the general population. Cognitive impairment and depress...

Charlotte Chruzander, Charlotte Ytterberg, Kristina Gottberg, Ulrika Einarsson, Lotta Widén Holmqvist, Sverker Johansson 57-63

Circulating levels of adipokines in Parkinson's disease

03 February 2014

Abstract: Introduction: Adipokines are adipocyte-derived secretory factors, which have functions in satiety, energetic homeostasis, insulin sensitivity, vascular disease and also immune response. Park...

Natália Pessoa Rocha, Paula Luciana Scalzo, Izabela Guimarães Barbosa, Mariana Soares de Sousa, Isabela Boechat Morato, Érica Leandro Marciano Vieira, Paulo Pereira Christo, Helton José Reis, Antônio Lúcio Teixeira 64-68

Load-induced changes in older individual's hand-finger tremor are ameliorated with targeting

06 February 2014

Abstract: The purpose of this study was to investigate hand–finger tremor dynamics when a load was applied to the finger in a group of healthy older adults. Moreover, we sought to determine if project...

Justin J. Kavanagh, Troy J. Cross, Karl M. Newell, Steven Morrison 69-74

Rutin improves functional outcome via reducing the elevated matrix metalloproteinase-9 level in a photothrombotic focal ischemic model of rats

10 February 2014

Abstract: Background: Blood–brain barrier (BBB) disruption mediated by proteases plays a pivotal role in neural tissue damage after acute ischemic stroke. In an animal stroke model, the activation of ...

Jae-Won Jang, Jung-Kil Lee, Hyuk Hur, Tae-Wan Kim, Sung-Pil Joo, Min-Sheng Piao 75-80

Non-viral human proGDNF gene delivery to rat bone marrow stromal cells under ex vivo conditions

10 February 2014

Abstract: Glial cell line-derived neurotrophic factor (GDNF) is one of the most important proteins playing a pivotal role in growing and repairing of the nervous system. GDNF therapy is one of the sug...

Ali Noori-Zadeh, Seyed Alireza Mesbah-Namin, Taki Tiraihi, Masoumeh Rajabibazl, Taher Taheri 81-86

Arterial spin-labeling magnetic resonance imaging for diagnosis of late seizure after stroke

10 February 2014

Abstract: Background and purpose: Arterial spin labeling (ASL) is a non-invasive modality of magnetic resonance imaging (MRI) used to evaluate cerebral perfusion without a contrast agent. The usefulne...

Yosuke Miyaji, Mutsumi Yokoyama, Yuichi Kawabata, Hideto Joki, Yuji Kushi, Yasutaka Yokoi, Jo Sasame, Shunsuke Seki, Kentaro Mori, Tomoya Kamide, Akira Tamase, Hiroshi Shima, Motohiro Nomura, Yoshihisa Kitamura, Fumiaki Tanaka 87-90

CR1, ABCA7, and APOE genes affect the features of cognitive impairment in Alzheimer's disease

18 February 2014

Abstract: Background: The genetic factors that determine the heterogeneity of cognitive impairment in Alzheimer's disease (AD) patients have been rarely reported. We aimed to investigate the associati...

Sun Ju Chung, Mi-Jung Kim, Young Jin Kim, Juyeon Kim, Sooyeoun You, Eun Hye Jang, Seong Yoon Kim, Jae-Hong Lee 91-96

In-vitro thrombogenicity assessment of polymer filament modified and native platinum embolic coils

18 February 2014

Abstract: Background: Embolic coils have been used to treat intracranial aneurysms using an endovascular approach for more than two decades. However, significant aneurysm recanalization rates have bee...

Gaurav Girdhar, Megan Read, JiHae Sohn, Chirag Shah, Sanjay Shrivastava 97-101

Pilot assessment of a comfort scale in stroke patients

18 February 2014

Abstract: Introduction: Comfort/discomfort (C/D) is an important factor of quality of life (QoL). Brain damage is a major source of discomfort. We developed a questionnaire for assessing C/D in daily ...

Caroline Rogeau, Franck Beaucamp, Etienne Allart, Walter Daveluy, Marc Rousseaux 102-107

Incidence of idiopathic normal pressure hydrocephalus (iNPH): A 10-year follow-up study of a rural community in Japan

24 March 2014

Abstract: Background: The epidemiology and pathophysiology of iNPH remain unclear. We aimed to investigate the incidence of iNPH in elderly inhabitants of the community, and to identify how ventriculo...

Chifumi Iseki, Yoshimi Takahashi, Manabu Wada, Toru Kawanami, Makoto Adachi, Takeo Kato 108-112

Etiological mechanisms of isolated pontine infarcts based on arterial territory involvement

24 February 2014

Abstract: Background: Pontine infarcts can be classified into four regions based on the vascular anatomy: anteromedial, anterolateral, lateral and posterior. The purpose of this study was to determine...

Junpei Kobayashi, Tomoyuki Ohara, Kazuo Minematsu, Kazuyuki Nagatsuka, Kazunori Toyoda 113-117

Accuracy of osmophobia in the differential diagnosis between migraine and tension-type headache

24 February 2014

Abstract: Our objective was to determine the accuracy parameters of osmophobia in the differential diagnosis between migraine and tension-type headache. Migraine or tension-type headache patients, dia...

Raimundo Pereira Silva-Néto, Mário Fernando Pietro Peres, Marcelo Moraes Valença 118-122

The role of N-methyl-D-aspartate receptor in Alzheimer's disease

18 February 2014

Abstract: Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive disorder and memory dysfunction. This kind of cognitive impairment is closely related to synaptic plasticit...

Junsi Zhang, Yanna Li, Jing Xu, Zhou Yang 123-129

Deep tiny flow voids along middle cerebral artery atherosclerotic occlusions: A high-resolution MR imaging study

14 February 2014

Abstract: Background and purpose: We aim to report the "deep tiny flow voids" (DTFV), a unique HR-MRI finding suggestive of deep collateral vessels along middle cerebral artery (MCA) occlusions. Metho...

Wei-Hai Xu, Ming-Li Li, Jing-Wen Niu, Feng Feng, Zheng-Yu Jin, Shan Gao 130-133

Viewing condition dependence of the gaze-evoked nystagmus in Arnold Chiari type 1 malformation

21 February 2014

Abstract: Saccadic eye movements rapidly shift gaze to the target of interest. Once the eyes reach a given target, the brainstem ocular motor integrator utilizes feedback from various sources to assur...

Fatema F. Ghasia, Deepak Gulati, Edward L. Westbrook, Aasef G. Shaikh 134-139

Plasma factor VIII in non-puerperal cerebral venous thrombosis: A prospective case–control study

21 February 2014

Abstract: Elevated plasma factor VIII (FVIII) is increasingly recognized as an independent risk factor for thrombotic diseases. Our aim was to evaluate the association of increased plasma FVIII with c...

Ravi K. Anadure, Dindagur Nagaraja, Rita Christopher 140-143

Downregulated RASD1 and upregulated miR-375 are involved in protective effects of calycosin on cerebral ischemia/reperfusion rats

18 February 2014

Abstract: Isoflavone calycosin is a typical phytoestrogen extracted from Chinese medical herb Radix Astragali. It has been reported that estrogens could provide neuroprotective effects, and dietary in...

Yong Wang, Xianhong Dong, Zhengzhao Li, Wenbo Wang, Jing Tian, Jian Chen 144-148

Swallowing impairment and pulmonary dysfunction in Parkinson's disease: The silent threats

25 February 2014

Abstract: Introduction: Swallowing disorders and respiratory impairment are frequent in Parkinson's disease (PD) patients, and aspiration pneumonia remains the leading cause of death among these subje...

Larissa Monteiro, Adelmir Souza-Machado, Patrícia Pinho, Marília Sampaio, Ana Caline Nóbrega, Ailton Melo 149-152

Acute vertigo due to hemispheric stroke: A case report and comprehensive review of the literature

03 March 2014

Abstract: Acute cortical lesions rarely cause vertigo. We report a 51-year-old patient presenting with an acute vestibular syndrome including spontaneous vertigo and nystagmus, lateropulsion and nause...

Michael von Brevern, Sina Süßmilch, Daniel Zeise 153-156

The impact of stroke on cognitive processing — A prospective event-related potential study

27 February 2014

Abstract: Background and purpose: Stroke is often associated with cognitive decline which can be evaluated by event-related potentials (ERP). So far, only little is known about the impact of stroke on...

Leandra Stahlhut, Karl-Heinz Grotemeyer, Ingo-W. Husstedt, Stefan Evers 157-163

Blood pressure variability and stroke outcome in patients with internal carotid artery occlusion

03 March 2014

Abstract: Purpose: The aim of this study was to evaluate the relationship between arterial blood pressure (BP) variability during the acute phase and the 3-month outcome in ischemic stroke patients wi...

Laura Buratti, Claudia Cagnetti, Clotilde Balucani, Giovanna Viticchi, Lorenzo Falsetti, Simona Luzzi, Simona Lattanzi, Leandro Provinciali, Mauro Silvestrini 164-168

Decreased physical activity predicts cognitive dysfunction and reduced cerebral blood flow in heart failure

03 March 2014

Abstract: Objective: Cognitive impairment in heart failure (HF) is believed to result from brain hypoperfusion subsequent to cardiac dysfunction. Physical inactivity is prevalent in HF and correlated ...

Michael L. Alosco, Mary Beth Spitznagel, Ronald Cohen, Naftali Raz, Lawrence H. Sweet, Richard Josephson, Joel Hughes, Jim Rosneck, John Gunstad 169-175

Long-term prognosis for hearing recovery in stroke patients presenting vertigo and acute hearing loss

03 March 2014

Abstract: Background and purpose: Vertebrobasilar ischemic stroke (VBIS) can cause acute hearing loss (AHL) because the vertebrobasilar system supplies most of the auditory system including the inner ...

Hyun-Ah Kim, Byung-Chan Lee, Jeong-Ho Hong, Chang-Ki Yeo, Hyon-Ah Yi, Hyung Lee 176-182

Normal protein content but abnormally inhibited enzyme activity in muscle carnitine palmitoyltransferase II deficiency

06 March 2014

Abstract: The biochemical consequences of the disease causing mutations of muscle carnitine palmitoyltransferase II (CPT II) deficiency are still enigmatic. Therefore, CPT II was characterized in musc...

Diana Lehmann, Stephan Zierz 183-188

Altered intrinsic functional connectivity of the salience network in childhood absence epilepsy

18 March 2014

Abstract: Intrinsic connectivity analysis provides an original way for evaluating functional impairments in epilepsy. Disturbances in the salience network (SN) have been positing an important interpla...

Cheng Luo, Tianhua Yang, Shipeng Tu, Jiayan Deng, Dongbo Liu, Qifu Li, Li Dong, Ilan Goldberg, Qiyong Gong, Dan Zhang, Dongmei An, Dong Zhou, Dezhong Yao 189-195

Management of relapsing–remitting multiple sclerosis in Latin America: Practical recommendations for treatment optimization

06 March 2014

Abstract: The Latin American MS Experts' Forum has developed practical recommendations on the initiation and optimization of disease-modifying therapies in patients with relapsing–remitting multiple s...

Jorge Correale, Patricio Abad, Regina Alvarenga, Soniza Alves-Leon, Elizabeth Armas, Jorge Barahona, Ricardo Buzó, Teresa Corona, Edgardo Cristiano, Fernando Gracia, Juan García Bonitto, Miguel Angel Macías, Arnoldo Soto, Darwin Vizcarra, Mark S. Freedman 196-206

Short Communications

Article TitleAuthor(s)Pages

Comparison of dopamine transporter decline in a patient with Parkinson's disease and normal aging effect

24 January 2014

Abstract: We report serial dopamine transporter (DAT) positron emission tomography (PET) scanning in a patient with Parkinson's disease (PD). Six months after motor symptom onset, the patient was diag...

Kenji Ishibashi, Keiichi Oda, Kiichi Ishiwata, Kenji Ishii 207-209

A novel SCARB2 mutation in progressive myoclonus epilepsy indicated by reduced β-glucocerebrosidase activity

03 February 2014

Abstract: Action myoclonus renal failure (AMRF) syndrome is a rare form of progressive myoclonus epilepsy with renal dysfunction related to mutations in the SCARB2 gene. This gene is involved in lysos...

Marsha Zeigler, Vardiella Meiner, J.P. Newman, Bettina Steiner-Birmanns, Ruth Bargal, Vivi Sury, Getu Mengistu, Or Kakhlon, Ina Leykin, Zohar Argov, Oded Abramsky, Alexander Lossos 210-213

Pseudotumoral brain lesion as the presenting feature of primary Sjögren's syndrome

10 February 2014

Abstract: Background: The frequency and type of central nervous system involvement in primary Sjögren's syndrome (pSS) remain controversial. Brain magnetic resonance imaging (MRI) abnormalities in pSS...

Samia Ben Sassi, Fatma Nabli, Adnene Boubaker, Imed Ben Ghorbel, Sonia Neji, Fayçal Hentati 214-216

Motor vehicle accidents and injuries in patients with idiopathic blepharospasm

07 February 2014

Abstract: Background: Blepharospasm can cause transient functional blindness that may cause catastrophic traffic accidents. Methods: Sixty-six patients in southern Taiwan with idiopathic blepharospasm...

Wen-Juh Hwang, Ching-Fang Tsai 217-219

Novel single base-pair deletion in exon 1 of XK gene leading to McLeod syndrome with chorea, muscle wasting, peripheral neuropathy, acanthocytosis and haemolysis

14 February 2014

Abstract: We present a 70-year-old male patient of Greek origin with choreatic movements of the tongue and face, lower limb muscle weakness, peripheral neuropathy, elevated creatinephosphokinase (CPK)...

Sarah Wiethoff, Georgia Xiromerisiou, Conceição Bettencourt, Anna Kioumi, Iakovos Tsiptsios, Athanasios Tychalas, Markousi Evaggelia, Kaltsounis George, Vasileios Makris, John Hardy, Henry Houlden 220-222

Catastrophic brain relapse in seronegative NMO after a single dose of natalizumab

27 February 2014

Abstract: Natalizumab, an effective treatment for MS, has been shown to exacerbate neuromyelitis optica (NMO) with aquaporin-4 antibodies, but whether this is the case in antibody negative NMO and aty...

Joanna Kitley, Nikos Evangelou, Wilhelm Küker, Anu Jacob, M. Isabel Leite, Jackie Palace 223-225

Visual text hallucinations of thoughts in an alexic woman

18 February 2014

Abstract: In this report we describe a patient with a clinical diagnosis of dementia with Lewy bodies, who had hallucinations of reading her thoughts in the air although she was alexic and unable to r...

Bun Yamagata, Hitomi Kobayashi, Hideki Yamamoto, Masaru Mimura 226-228

Combined CMV- and HSV-1 brainstem encephalitis restricted to medulla oblongata

03 March 2014

Abstract: We report a very rare case of a combined CMV- and HSV-1 isolated brainstem encephalitis restricted to medulla oblongata in a patient with advanced HIV disease. Neither limbic nor general ven...

J. Katchanov, G. Branding, H. Stocker 229-230

Superficial siderosis associated with aceruloplasminemia. Case report

06 March 2014

Abstract: A 63-year-old woman with a past history of right subdural hematoma (SDH) at the age of 61years was referred to our hospital under a suspicion of aceruloplasminemia (ACP). A neurological exam...

Akira Matsushima, Toshikazu Yoshida, Kunihiro Yoshida, Shinji Ohara, Yasuko Toyoshima, Akiyoshi Kakita, Shu-ichi Ikeda 231-234

Letters to the Editor

Article TitleAuthor(s)Pages

The importance of using a proper technique and accurate seeding of regions-of-interest in diffusion tensor tractography

31 January 2014

We read with interest a recent study published in this journal "Distribution of the corticobulbar tract in the internal capsule" by Yim et al. . Yim et al. used probabilistic tractography to map corti...

Arash Kamali, Khader M. Hasan 235-236

Tractography of the corticobulbar tract

27 January 2014

I appreciate the important comments of Kamali et al. First, those authors mentioned the possible false negativity of the results concerning the corticobulbar tracts, because of their high angulation a...

Jong Hun Kim, Seun Jeon, Jong Min Lee, Jun Hong Lee 237-238

Recurrent aseptic meningitis with reversible cerebral vasoconstriction

07 March 2014

Mollaret's meningitis is a syndrome of recurrent aseptic meningitis with self-limited, focal neurologic dysfunction . The pathogenesis for these deficits remains unclear, although many cases have been...

Lester Y. Leung, Molly Brett, Jonathan Zurawski, Sandeep Kumar 239-240