JNS-cover.jpgJournal of Neurological Sciences

Vol 337 | No. 1-2 | 15 February 2014 | Pages 1-246


Article TitleAuthor(s)Pages

Assessment of cognitive impairment in amyotrophic lateral sclerosis

09 December 2013

The nihilistic attitude towards amyotrophic lateral sclerosis (ALS) has been adopted for decades due to the terrible outcome of the disease. Increased survival time and improved quality of life due to...

F.J. Rodríguez de Rivera, H.A. Rambold, E. Díez-Tejedor 1-2


Article TitleAuthor(s)Pages

A systematic review of closure versus medical therapy for preventing recurrent stroke in patients with patent foramen ovale and cryptogenic stroke or transient ischemic attack

02 December 2013

Abstract: The optimal treatment for secondary prevention in patients who have a patent foramen ovale (PFO) and history of cryptogenic stroke is still uncertain and controversial. In view of this, we p...

Linkun Chen, Shuguang Luo, Lingwan Yan, Weijia Zhao 3-7

Original Articles

Article TitleAuthor(s)Pages

Erythrocytes' antioxidative capacity as a potential marker of oxidative stress intensity in neuroinflammation

25 November 2013

Abstract: The study is designed to assess the oxidative stress intensity in erythrocytes obtained from patients in different clinical phenotypes of neuroinflammation, defined as clinically isolated sy...

Srdjan Ljubisavljevic, Ivana Stojanovic, Tatjana Cvetkovic, Slobodan Vojinovic, Dragan Stojanov, Dijana Stojanovic, Nikola Stefanovic, Dusica Pavlovic 8-13

Clinical predictors and outcome of patients of acute stroke requiring ventilatory support: A prospective hospital based cohort study

02 December 2013

Abstract: The purpose of this study was to identify clinical factors which may help in predicting the requirement of support of mechanical ventilation (MV) in patients with stroke. This was a prospect...

Priya Gupta, Kameshwar Prasad, Amit Kumar, Pradeep Kumar, Rohit Bhatia, Manjari Tripathi 14-17

Long-term effects of dalfampridine in patients with multiple sclerosis

02 December 2013

Abstract: Background/objective: Dalfampridine is the extended-release formulation of 4-aminopyridine and is approved for the symptomatic treatment of impaired mobility in patients with multiple sclero...

T. Ruck, S. Bittner, O.J. Simon, K. Göbel, H. Wiendl, M. Schilling, S.G. Meuth 18-24

Temporal and regional patterns of Smad activation in the rat hippocampus following global ischemia

02 December 2013

Abstract: In this study, we examined the temporal and regional patterns of Smad activation in the rat hippocampus following global ischemia. We also examined the association between Smad activation an...

Takayuki Nakajima, Masafumi Yanagihara, Hideki Nishii 25-37

Analysis of the duration of migraine prophylaxis

04 December 2013

Abstract: To determine the minimum duration of migraine prophylaxis, after patients become pain-free. Migraine patients diagnosed according to criteria of International Classification of Headache Diso...

Raimundo Pereira Silva-Néto, Kelson James Almeida, Silvya Neri Bernardino 38-41

Gene expression profile in fibroblasts of Huntington's disease patients and controls

02 December 2013

Abstract: Huntington's disease is an inherited disorder caused by expanded stretch of consecutive trinucleotides (cytosine–adenosine–guanine, CAG) within the first exon of the huntingtin (HTT) gene on...

Eleonora Marchina, Silvia Misasi, Andrea Bozzato, Sergio Ferraboli, Chiara Agosti, Luca Rozzini, Giuseppe Borsani, Sergio Barlati, Alessandro Padovani 42-46

Safety and efficacy of recombinant human erythropoietin treatment of non-motor symptoms in Parkinson's disease

02 December 2013

Abstract: Background: Numerous animal studies and clinical trials have demonstrated that erythropoietin (EPO) has therapeutic effects in ischemic and degenerative diseases. However, few clinical trial...

Wooyoung Jang, Jinse Park, Kyung Jin Shin, Joong-Seok Kim, Ji Sun Kim, Jinyoung Youn, Jin Whan Cho, Eungseok Oh, Jin Young Ahn, Ki-Wook Oh, Hee-Tae Kim 47-54

Clinical features in Guillain–Barré syndrome with anti-Gal-C antibody

02 December 2013

Abstract: Introduction: Guillain–Barré syndrome (GBS) has often been associated with antibodies to glycolipids, such as galactocerebroside (Gal-C), a component of myelin. Whether patients who have GBS...

Makoto Samukawa, Yukihiro Hamada, Motoi Kuwahara, Kazuo Takada, Makito Hirano, Yoshiyuki Mitsui, Masahiro Sonoo, Susumu Kusunoki, the Japanese GBS Study Group 55-60

Investigations of single nucleotide polymorphisms in folate pathway genes in Chinese families with neural tube defects

09 December 2013

Abstract: Aims: We investigated the hypothesis that there are interactions between SNPs in folate metabolism pathway genes and environmental risk factors to the etiology of neural tube defects (NTDs)....

Jian Liu, Jing Qi, Xiao Yu, Jie Zhu, Lixia Zhang, Qin Ning, Xiaoping Luo 61-66

The coexistence of well- and ill-being in persons with multiple sclerosis, their caregivers and health professionals

02 December 2013

Abstract: Background: Studies on emotional distress and health-related quality of life (HRQOL) broadened the traditional bio-medical focus in MS research, but little attention was paid to general well...

Marta Bassi, Monica Falautano, Sabina Cilia, Benedetta Goretti, Monica Grobberio, Marianna Pattini, Erika Pietrolongo, Rosa Gemma Viterbo, Maria Pia Amato, Miriam Benin, Alessandra Lugaresi, Vittorio Martinelli, Enrico Montanari, Francesco Patti, Maria Trojano, Antonella Delle Fave 67-73

Neuroprotective effects of Nigella sativa extract on cell death in hippocampal neurons following experimental global cerebral ischemia-reperfusion injury in rats

06 December 2013

Abstract: Background: Global cerebral ischemia followed by reperfusion, leads to extensive neuronal damage, particularly the neurons in the hippocampal CA region. Recent studies have demonstrated that...

R. Hobbenaghi, J. Javanbakht, Sh. Sadeghzadeh, D. Kheradmand, F.S. Abdi, M.H. Jaberi, M.R. Mohammadiyan, F. Khadivar, Y. Mollaei 74-79

Quantitative analysis of brainstem atrophy on magnetic resonance imaging in chronic progressive neuro-Behçet's disease

02 December 2013

Abstract: Objectives: To examine whether quantitative analysis of the brainstem areas on magnetic resonance imaging (MRI) scans is useful for diagnosis as well as evaluation of disease activity in chr...

Hirotoshi Kikuchi, Maki Takayama, Shunsei Hirohata 80-85

Efficacy and safety of botulinum toxin type A (Dysport) for the treatment of post-stroke arm spasticity: Results of the German–Austrian open-label post-marketing surveillance prospective study

23 December 2013

Abstract: The current practice in Germany and Austria, and the safety and efficacy of botulinum toxin type A (BoNT-A; Dysport) in the treatment of patients with post-stroke arm spasticity (with no fix...

Wolfgang H. Jost, Harald Hefter, Andrea Reissig, Katja Kollewe, Joerg Wissel 86-90

Cauda equina involvement in Susac's syndrome

02 December 2013

Abstract: Susac's syndrome is a rare autoimmune microangiopathy characterized by the clinical triad of encephalopathy, branch retinal artery occlusions, and sensorineural hearing loss. In many cases, ...

Andrew M. Allmendinger, Robert M. Mallery, Cynthia M. Magro, Nancy Wang, Robert A. Egan, Martin A. Samuels, Alison Callahan, Narayan Viswanadhan, Roman A. Klufas, Liangge Hsu, Sashank Prasad 91-96

A model of acute compressive spinal cord injury with a minimally invasive balloon in goats

13 December 2013

Abstract: Research into spinal cord injury depends upon animal models of trauma. While investigations using small animals have yielded critical insights into the cellular mechanisms of neurotrauma, no...

Peng Cao, Yuhuang Zheng, Tao Zheng, Changwei Sun, Jiong Lu, Todd Rickett, Riyi Shi 97-103

Cerebrolysin reduces amyloid-β deposits, apoptosis and autophagy in the thalamus and improves functional recovery after cortical infarction

09 December 2013

Abstract: Focal cerebral infarction causes amyloid-β (Aβ) deposits and secondary thalamic neuronal degeneration. The present study aimed to determine the protective effects of Cerebrolysin on Aβ depos...

Shihui Xing, Jian Zhang, Chao Dang, Gang Liu, Yusheng Zhang, Jingjing Li, Yuhua Fan, Zhong Pei, Jinsheng Zeng 104-111

Longitudinal changes in brain volumes and cerebrovascular lesions on MRI in patients with manifest arterial disease: The SMART-MR study

05 December 2013

Abstract: We estimated the progression of brain atrophy and cerebrovascular lesions on MRI in a prospective cohort of patients with various manifestations of arterial disease. Within the SMART-MR stud...

Pieternella H. van der Veen, Majon Muller, Koen L. Vincken, Theo D. Witkamp, Willem P.T.M. Mali, Yolanda van der Graaf, Mirjam I. Geerlings, on behalf of the SMART-MR Study Group 112-118

JCV epidemiology in MS (JEMS)—Epidemiology of anti-JCV antibody prevalence in multiple sclerosis patients—Portuguese data

24 December 2013

Abstract: Background: Progressive multifocal leukoencephalopathy, caused by oligodendrocyte lytic infection by JCVirus, is a growing concern for patients undergoing immune modulatory therapies for tre...

Ana Martins da Silva, Maria Ernestina Santos, On behalf of the Portuguese JEMS Study Investigators 119-122

Hypomethylation of SNCA in blood of patients with sporadic Parkinson's disease

09 December 2013

Abstract: SNCA is a pathogenic gene identified in rare familial PD, and over-expression of SNCA was suggested in the pathogenesis of familial and sporadic PD. Rep1 polymorphism of SNCA was associated ...

San-xi Ai, Qian Xu, Ya-cen Hu, Cheng-yuan Song, Ji-feng Guo, Lu Shen, Chun-rong Wang, Ri-li Yu, Xin-xiang Yan, Bei-sha Tang 123-128

Differences in neuronal damage and gliosis in the hippocampus between young and adult gerbils induced by long duration of transient cerebral ischemia

09 December 2013

Abstract: Response to cerebral ischemia in young animals was very different from that in the adult. The aim of this study was to investigate differences in neuronal death and gliosis in the hippocampa...

Bing Chun Yan, Taek Geun Ohk, Ji Hyeon Ahn, Joon Ha Park, Bai Hui Chen, Jae-Chul Lee, Choong Hyun Lee, Myoung Cheol Shin, In Koo Hwang, Seung Myung Moon, Jun Hwi Cho, Moo-Ho Won 129-136

Postsurgical inflammatory neuropathy: A report of five cases

11 December 2013

Abstract: Background: Clinical and pathologic descriptions of postsurgical inflammatory neuropathy have been reported but this condition is still under recognized. Methods: We reviewed 5 cases of a bi...

Watcharasarn Rattananan, Pariwat Thaisetthawatkul, P. James B. Dyck 137-140

Autonomic dysfunction in different subtypes of post-acute ischemic stroke

09 December 2013

Abstract: Objectives: Central autonomic impairment is frequent in ischemic stroke at acute or chronic stages. The mechanism by which these symptoms occur in patients with ischemic stroke has not been ...

L. Xiong, H.W. Leung, X.Y. Chen, W.H. Leung, O.Y. Soo, K.S. Wong 141-146

Interleukin 2 receptor α chain gene polymorphisms and risks of multiple sclerosis and neuromyelitis optica in southern Japanese

16 December 2013

Abstract: Background: Interleukin 2 receptor α subunit (IL2RA) is a genetic risk for multiple sclerosis (MS) in Caucasians. However, the association between MS and IL2RA in Japanese idiopathic demyeli...

Gulibahaer Ainiding, Yuji Kawano, Shinya Sato, Noriko Isobe, Takuya Matsushita, Satoshi Yoshimura, Tomomi Yonekawa, Ryo Yamasaki, Hiroyuki Murai, Jun-ichi Kira, the South Japan Multiple Sclerosis Genetics Consortium 147-150

Significance of acute multiple infarcts in multiple cerebral circulations on initial diffusion weighted imaging in stroke patients

13 December 2013

Abstract: Objectives: We attempted to assess the frequency, clinical and neuroradiological features of concomitant Acute Multiple Infarcts in Multiple Cerebral Circulations (AMIMCC) and to classify th...

S. Depuydt, M. Sarov, C. Vandendries, T. Guedj, C. Cauquil, P. Assayag, O. Lambotte, D. Ducreux, C. Denier 151-155

Oxidative balance, homocysteine, and uric acid levels in older patients with Late Onset Alzheimer's Disease or Vascular Dementia

09 December 2013

Abstract: This study aimed to investigate whether Late Onset Alzheimer's Disease (LOAD) and Vascular Dementia (VAD) might be associated with a distinct profile of oxidative stress (OxS) peripheral mar...

Carlo Cervellati, Arianna Romani, Davide Seripa, Eleonora Cremonini, Cristina Bosi, Stefania Magon, Angelina Passaro, Carlo M. Bergamini, Alberto Pilotto, Giovanni Zuliani 156-161

Cerebral white matter disease is independently associated with BPSD in Alzheimer's disease

30 December 2013

Abstract: Objectives: To study the association between cerebral white matter disease and burden of behavioral and psychological symptoms (BPSD) among patients with moderate to severe AD. Methods: Pati...

Nagaendran Kandiah, Russell Chander, Angeline Zhang, Cheong Chin Yee 162-166

Relationship between poor decision-making process and fatigue perception in Parkinson's disease patients

18 December 2013

Abstract: Background: Fatigue is a common non-motor symptom in Parkinson's disease patients. The reasons for its perception are not completely understood. One suggested possibility might be that perce...

Naia Sáez-Francàs, Jorge Hernández-Vara, Margarita Corominas-Roso, José Alegre, Carlos Jacas, Miguel Casas 167-172

Camptocormia in Chinese patients with Parkinson's disease

20 December 2013

Abstract: To investigate the frequency and clinical characteristics of camptocormia in Chinese PD patients, we included 705 patients with PD and studied the clinical features and prevalence of camptoc...

Wei Song, Xiaoyan Guo, Ke Chen, Rui Huang, Bi Zhao, Bei Cao, YongPing Chen, Hui-Fang Shang 173-175

A functional polymorphism in the promoter region of MAOA gene is associated with daytime sleepiness in healthy subjects

20 December 2013

Abstract: Excessive daytime sleepiness (EDS) is one of the main causes of car and industrial accidents and it is associated with increased morbidity and alterations in quality of life. Prevalence of E...

Diego A. Ojeda, Carmen L. Niño, Sandra López-León, Andrés Camargo, Ana Adan, Diego A. Forero 176-179

Interferon-beta-1a treatment has a positive effect on quality of life of relapsing–remitting multiple sclerosis: Results from a longitudinal study

15 January 2014

Abstract: Purpose: The impact of interferon beta (IFNβ) therapy on a patient's quality of life (QoL) has not been completely clarified. This multicenter, independent, observational and longitudinal st...

Francesco Patti, Angelo Pappalardo, Enrico Montanari, Ilaria Pesci, Valeria Barletta, Carlo Pozzilli 180-185

Arundic acid (ONO-2506) inhibits secondary injury and improves motor function in rats with spinal cord injury

19 December 2013

Abstract: Background: Arundic acid (ONO-2506) inhibits the production and release of S100 protein from astrocytes. While numerous studies have assessed the effect of ONO-2506 in the diseased brain, to...

Mitsuru Hanada, Ryuichi Shinjo, Michihito Miyagi, Tatsuya Yasuda, Koji Tsutsumi, Yuki Sugiura, Shiro Imagama, Naoki Ishiguro, Yukihiro Matsuyama 186-192

Distinct acoustic features in spinal and bulbar muscular atrophy patients with laryngospasm

23 December 2013

Abstract: Objective: Laryngospasm is a sudden onset of transient respiratory difficulty that is perceived as life-threatening by patients with spinal and bulbar muscular atrophy (SBMA). The purpose of...

Seiya Tanaka, Haruhiko Banno, Masahisa Katsuno, Keisuke Suzuki, Noriaki Suga, Atsushi Hashizume, Tomoo Mano, Amane Araki, Hirohisa Watanabe, Hiroaki Adachi, Hiroshi Tatsumi, Masahiko Yamamoto, Gen Sobue 193-200

The modulation of rolandic oscillation induced by digital nerve stimulation and self-paced movement of the finger: A MEG study

24 December 2013

Abstract: Background: The rolandic cortex exhibits spontaneous rhythmic activity. This oscillation can be modulated by somatosensory stimulation and voluntary movement. The purpose of this study is to...

Rei Enatsu, Takashi Nagamine, Jun Matsubayashi, Hitoshi Maezawa, Takayuki Kikuchi, Hidenao Fukuyama, Nobuhiro Mikuni, Susumu Miyamoto, Nobuo Hashimoto 201-211

Short Communications

Article TitleAuthor(s)Pages

Association of a paraneoplastic motor neuron disease with anti-Ri antibodies and a novel SOD1 I18del mutation

02 December 2013

Abstract: Introduction: Whether motor neuron diseases (MNDs) can be considered in some cases of paraneoplastic syndromes is controversial. We report a case of rapidly progressive motor neuronopathy fo...

Capucine Diard-Detoeuf, Audrey Dangoumau, Nadège Limousin, Julien Biberon, Patrick Vourc'h, Christian R. Andres, Bertrand de Toffol, Julien Praline 212-214

Motor-dominant polyneuropathy due to IgM monoclonal antibody against disialosyl gangliosides in a patient with mantle cell lymphoma

09 December 2013

Abstract: A rapidly progressive motor-dominant neuropathy associated with IgM monoclonal antibody against gangliosides with disialosyl residues, GD3, GD1b, GT1b, and GQ1b, in a 60-year-old Japanese ma...

Akio Mori, Yuji Ueno, Takuma Kuroki, Yasunobu Hoshino, Hideki Shimura, Yasunobu Sekiguchi, Masaaki Noguchi, Yukihiro Hamada, Susumu Kusunoki, Nobutaka Hattori, Takao Urabe 215-218

Exome sequencing reveals a novel MRE11 mutation in a patient with progressive myoclonic ataxia

16 December 2013

Abstract: Progressive myoclonic ataxia (PMA) is a clinical syndrome defined as progressive ataxia and myoclonus and infrequent seizures in the absence of progressive dementia. Due to the extremely het...

Ryosuke Miyamoto, Hiroyuki Morino, Akio Yoshizawa, Yoshimichi Miyazaki, Hirofumi Maruyama, Nagahisa Murakami, Kei Fukada, Yuishin Izumi, Shinya Matsuura, Ryuji Kaji, Hideshi Kawakami 219-223

Paraneoplastic limbic encephalitis with prominent neuropsychiatric apathy

06 January 2014

Abstract: The spectrum of paraneoplastic neurologic syndromes has increased with the description of encephalitis associated with antibodies against cell surface and synaptic proteins. Subacute cogniti...

Fábio Henrique de Gobbi Porto, Artur Martins Novaes Coutinho, Leandro Tavares Lucato, Lívia Spíndola, Carla Rachel Ono, Sonia Maria Dozzi Brucki, Carlos Alberto Buchpiguel, Ricardo Nitrini 224-227

A case of Susac syndrome with cervical spinal cord involvement on MRI

23 December 2013

Abstract: We describe a typical case presentation of Susac syndrome with a novel MRI finding of cervical spinal cord involvement. A 25-year-old, 14-week gestation white woman presented with two episod...

Le H. Hua, Stacy L. Donlon, Darin T. Okuda 228-231

Intracranial fibromuscular dysplasia presenting as various ocular manifestations

20 December 2013

Abstract: Fibromuscular dysplasia (FMD) is a nonatherosclerotic, noninflammatory vascular disease that mainly affects renal, extracranial carotid, and vertebral arteries. Intracranial FMD is uncommon ...

Jae-Hwan Choi, Jaeho Jung, Kyung-Pil Park, Seung Kuk Baik, Kyung Un Choi, Kwang-Dong Choi, Hee-Young Choi, Jong-Hoon Shin 232-234

Evidence of T-cell mediated neuronal injury in stiff-person syndrome with anti-amphiphysin antibodies

08 January 2014

Abstract: Paraneoplastic stiff-person syndrome (SPS) has been associated with antibodies against amphiphysin. Current evidence supports a pathogenic role for anti-amphiphysin antibodies. A 74-year-old...

Mervyn Q.W. Poh, Neil G. Simon, Michael E. Buckland, Elizabeth Salisbury, Shaun Watson 235-237

Letters to the Editor

Article TitleAuthor(s)Pages

Does a location predilection exist for warfarin associated intracerebral hemorrhage?

27 November 2013

I have read, with great interest, a recently published article in the Journal of Neurological Sciences by Ma et al. titled 'Warfarin-associated intracerebral hemorrhage: Volume, anticoagulation intens...

Dale Ding 238

Warfarin therapy and predilection for infratentorial hemorrhage

27 November 2013

We read with interest the letter from Dr. Ding regarding our article in which we showed that warfarin-related intracerebral hemorrhage (ICH) demonstrated a predilection for brainstem location. We furt...

Minmin Ma, Bernard Yan 239

Fronto-central monomorphic theta activity as EEG pattern of ictal psychosis

02 December 2013

We read with extreme interest the paper by Takaya et al. published on the Journal of the Neurological Sciences in 2005 . The authors reported the history of a 69-year-old woman who presented a non-con...

C. Liguori, A. Romigi, M. Albanese, M.G. Marciani, F. Izzi, R. Ludovisi, A. Nitti, F. Placidi 240-242
Perverted head-shaking and positional downbeat nystagmus in pregabalin intoxication

24 December 2013

Abstract: Dizziness and ataxia are known adverse effects of pregabalin, but characteristic oculomotor signs in pregabalin intoxication have not been reported. Here we describe a patient who displayed ...

Jeong-Yoon Choi, Young-Min Park, Yeon Sun Woo, Sung Un Kim, Jin-Man Jung, Do-Young Kwon 243-244

Book Reviews

Article TitleAuthor(s)Pages

Book review

30 December 2013

Neuroscientists and parents alike would agree that the adolescent brain is one of the most complex and perplexing structures encountered. This period of development is a tumultuous yet critical time, ...

Mitchel T. Williams 245

Book review

30 December 2013

Curiosity about the nervous system has been present since ancient times. Indeed, Hippocrates and Galen's studies of the human nervous system laid the foundations of modern neuroscience. Today, the fie...

Mitchel T. Williams 245

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