Author: Ontiveros F, Mattson WI, Wilson CS, Poisson KE, Hoskinson KR, McAllister AS, Webb AI, Douma A, Nelson EE
Editor's Choice
Journal of the Neurological Sciences | Evidence for compromised function of the glymphatic system in pediatric acquired demyelinating disorders
Article Link: https://doi.org/10.1016/j.jns.2026.125871
A new study explores glymphatic system dysfunction in children with pediatric acquired demyelinating syndromes (PADS), highlighting a potential but under-recognised mechanism in neurological disease. While disruptions to the brain’s waste clearance system have been identified in adults, their role in paediatric cases has remained largely unclear.
Using advanced diffusion imaging (DTI-ALPS), researchers found significantly reduced glymphatic function in children with PADS compared to healthy controls. These changes appeared independent of cognitive performance and conventional imaging markers, suggesting the glymphatic system may represent a distinct pathway of disease activity, with some signs of partial recovery over time.
Read the full article for a deeper look at how glymphatic dysfunction could contribute to paediatric demyelinating disorders and its potential as a novel biomarker.
Web design by Tribal Systems