Author: Nakase T, Takano Y, Nomura S, Baek HW, Takayama S, Ono R, Abe M, Ishii T, Tatewaki Y, Taki Y.
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Journal of the Neurological Sciences | Association of symptoms of neuropsychological long COVID with imaging and plasma biomarkers.
Article Link: https://doi.org/10.1016/j.jns.2026.125808
This study explores the neurological mechanisms behind “brain fog” and other cognitive symptoms associated with Long COVID by analysing brain imaging and blood biomarkers in affected patients. Using MRI, cerebral blood flow imaging, and a range of neuropsychological tests, researchers identified associations between cognitive performance, anxiety and depression scores, and changes in blood flow in specific brain regions, particularly the occipital and parietal lobes.
Cognitive test results were also linked with blood biomarkers including neurofilament light chain and glial fibrillary acidic protein, suggesting measurable neurological changes may underlie these symptoms.
Read the full article to learn more about the imaging findings, biomarkers, and implications for understanding neuropsychological long COVID.
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