Utility of MR fingerprinting in differentiating epileptogenic from non-epileptogenic cortical malformations

Authors: Kochi R, Su TY, Punia V, Morris S, Murakami H, Wang X, Blümcke I, Jones SE, Najm I, Alexopoulos AV, Ma D.

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Journal of the Neurological Sciences REVIEW ARTICLE | Volume 476, 123651 August 11, 2025

DOI: https://doi.org/10.1016/j.jns.2025.123651

This study investigates the potential of magnetic resonance fingerprinting (MRF) as a non-invasive method to differentiate epileptogenic from non-epileptogenic cortical malformations. This study investigates the potential of magnetic resonance fingerprinting (MRF) as a non-invasive method to differentiate epileptogenic from non-epileptogenic cortical malformations.

Quantitative MRF metrics, especially GM T1, hold promise as a non-invasive tool to to differentiate epileptogenic from non-epileptogenic cortical malformations. The authors state that their approach could aid SEEG implantation and surgical planning when complex/multiple cortical malformations are present.