[WCN23_Scientific Session]

The Neurological Complications of Diabetes, Prediabetes and Obesity

DYSLIPIDEMIA AND HYPERGLYCEMIA: TWO FACES OF PERIPHERAL NEUROPATHY 
Eva L. Feldman (United States of America)

THE BURDEN OF DIABETES AND DIABETIC NEUROPATHY IN INDIA
Eva L. Feldman (United States of America)

TREATING PERIPHERAL NEUROPATHY: NEW GUIDELINES ON PAIN AND PAIN MANAGEMENT
Gordon Smith (United States of America)

Peripheral neuropathy, a symmetrical distal-to-proximal loss of peripheral nerve function, occurs in individuals with diabetes, prediabetes, and obesity. Hyperglycemia is a major peripheral neuropathy risk factor, but glycemic control only slows progression in patients with type 1 diabetes. Glycemic control offers only modest benefits for individuals with type 2 diabetes, likely due to the high prevalence of comorbid obesity. Peripheral neuropathy pathophysiology is complex and occurs in the context of both hyperglycemia and dyslipidemia through bioenergetic failure in peripheral nerves secondary to their unique anatomy. Pain is highly prevalent and occurs through peripheral and central mechanisms. Current management focuses on controlling diabetes, obesity, and pain, but remains suboptimal. Research is on-going to identify specific molecular pathways to develop mechanism-based therapies and investigate lifestyle interventions.