Journal of the Neurological Sciences issue 486 now available

Prevalence and attribution of polyneuropathy in p.V142I (V122I) hereditary transthyretin amyloidosis

Published online: April 14, 2026

A new study examines polyneuropathy in individuals carrying the p.V142I transthyretin variant, the most common amyloid-associated mutation in the United States, particularly among Black populations. Although this variant is strongly linked to cardiac amyloidosis, its relationship with nerve involvement is less clear.

Read the full article for a deeper look at how careful clinical attribution can improve diagnosis and prevent unnecessary treatment in transthyretin amyloidosis.

Association between periventricular white matter hyperintensities around the anterior horn and CSF tap test responsiveness in idiopathic normal pressure hydrocephalus

Published online: April 6, 2026

A new study investigates whether the burden of periventricular white matter hyperintensities (WMH) can help predict response to cerebrospinal fluid tap testing in idiopathic normal pressure hydrocephalus (iNPH). These MRI changes are common in iNPH, but their clinical significance has been unclear.

Researchers found that greater WMH burden around the anterior horns was linked to worse baseline cognitive performance and less improvement after tap testing, particularly in executive function. Read the full article for a deeper look at how MRI-based WMH assessment could help guide treatment decisions in iNPH.

Efficacy and safety of conventional immunosuppressant therapies in elderly patients with Neuromyelitis optica spectrum disorder: A target trial emulation study

Published online: April 6, 2026

A new study evaluates the effectiveness and safety of immunosuppressive therapies in neuromyelitis optica spectrum disorder (NMOSD), with a focus on older patients. While these treatments are widely used to reduce relapse risk, evidence in elderly populations has been limited.

The findings suggest a trend toward reduced relapse rates in patients receiving immunosuppressive therapy, particularly in those under 60, although results were not statistically conclusive. Importantly, there was no clear overall increase in long-term infection risk, but a marked rise in serious infections was observed in the first six months of treatment among patients aged 60 and over.

Read the full article for a deeper look at how age may influence treatment decisions and safety considerations in NMOSD management.

Excellent agreement between automated deep learning-based and manual diffusion-weighted imaging infarct volume measurements in hyperacute stroke

Published online: April 10, 2026

A new study evaluates whether deep learning can reliably automate the measurement of infarct volume on diffusion-weighted MRI in patients with acute ischemic stroke treated with mechanical thrombectomy. These measurements are important for assessing infarct growth and predicting functional outcomes, but are typically time-consuming when done manually.

The results show that automated segmentation closely matches expert manual measurements, with very strong agreement and minimal bias across both hyperacute and follow-up scans. Importantly, the automated method performed equally well in predicting 3-month functional outcomes, suggesting it could provide a faster and scalable alternative for clinical use.

Read the full article for a deeper look at how AI-based imaging tools may streamline stroke assessment and support decision-making in acute care settings.