Journal of the Neurological Sciences issue 474 now available

Virus-specific antibody responses in multiple sclerosis patients treated with Ocrevus

Published online: May 11, 2025

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. B cell-depleting therapy is highly efficient in treating patients with relapsing-remitting MS (RRMS), although the mechanisms behind reducing disease progression with this type of therapy is unknown. Virus infections are associated with the onset of MS and antibodies to these have previously been suggested to supplement MS diagnostics. Based on this, we aimed to investigate the effect of Ocrevus (OCR) (B cell depletion therapy) on selected virus antibody levels.

Low-density lipoprotein cholesterol and severity of intracerebral hemorrhage: Insights from the SIREN study

Published online: May 25, 2025

An investigation on the link between LDL-C and markers of ICH severity among Indigenous West Africans in the Stroke Investigative Research and Education Network study.

ICH severity was evaluated using the Glasgow Coma Scale (GCS), Stroke Levity Scale (SLS), and the National Institutes of Health Stroke Scale (NIHSS). The serum LDL-c of the study population was dichotomized into <133 mg/dl and ≥ 133 mg/dl using the optimum threshold by the Youden Index after assessing the linear relationship between the serum LDL-c measured at admission and ICH severity markers. A multivariate-adjusted logistic regression was performed to identify the independent association of serum LDL-C with ICH severity.

Impact of blood viscosity on wake-up stroke: Analysis stratified by age and stroke subtype

Published online: May 26, 2025

Ischemic stroke occurring during sleep is termed wake-up stroke (WUS). Dehydration increases blood viscosity (BV) and evokes thrombogenesis, a common cause of WUS. This study aimed to investigate the association between BV and WUS, stratified by age and stroke subtype.

The subjects were consecutive patients with acute ischemic stroke onset-to-door time within 72 h. Hematocrit-derived BV at a high shear rate (300 s−1) was calculated using hematocrit at admission. We assessed association of BV with WUS in the whole cohort, stratified by age (elderly group, ≥65 years; younger group, <65 years) and by stroke subtype (small-vessel occlusion [SVO], large-artery atherosclerosis [LAA], cardioembolism [CE]) stratified by age.

Safety assessment of switching from fingolimod to siponimod: An Italian multicenter prospective study

Published online: May 10, 2025

Conducted a prospective observational study that included patients who had a confirmed diagnosis of SPMS at the time of study entry and had been treated with fingolimod for at least two years. Upon enrollment, patients either continued fingolimod (comparator group) or transitioned to siponimod (switch group) and were followed up for six months to assess disease activity and changes in laboratory parameters.