Autoimmune neuropathies: New guidelines and expert insights into clinical decision making

Image Source: Autoimmune neuropathies: New guidelines and expert insights into clinical decision making

Author: van Doorn PA, Sommer C, Rajabally YA.

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Article Link: https://www.jns-journal.com/article/S0022-510X(25)02279-8

A new review examines how updated guidelines are shaping the diagnosis and management of Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP). Although these immune-mediated neuropathies can appear similar early on, the article highlights key differences in disease course, progression timelines, and diagnostic criteria that are critical for accurate clinical decision-making.

The review outlines how clinicians integrate clinical presentation with cerebrospinal fluid analysis, electrodiagnostic studies, and selected antibody testing to distinguish GBS from CIDP and from other neurological conditions. It also emphasises the heterogeneity of GBS, describing typical forms, regional variants, and the Miller Fisher spectrum, while noting the limitations of subtype classification for guiding current treatment strategies. Particular attention is given to antecedent events, diagnostic uncertainty in early disease, and evidence-based use of therapies such as intravenous immunoglobulin and plasma exchange.

Read the full article for a comprehensive, guideline-driven discussion of diagnostic pathways, differential diagnoses, and treatment considerations for GBS and CIDP, and how personalised approaches are essential in managing these complex peripheral nerve disorders.