Cutting-edge stroke prevention strategies

Authors: Kaindl L, Hotz JF, Ferrari J.

Editor's Choice
eNeurologicalSci. Cutting-edge stroke prevention strategies.

DOI: https://doi.org/10.1016/j.ensci.2025.100561

Highlights

• Over 75 % of strokes are first events, emphasizing the need for early risk factor management.
• Non-modifiable factors help identify individuals at high risk for stroke, while modifiable factors offer targets for stroke prevention.
• Therapies like RNA-based treatments, GLP-1Ras, Colchicine and Factor XI inhibitors demonstrate potential in reducing cardiovascular risk.

Stroke represents a major public health problem, ranking as a leading cause of death and long-term disability worldwide. The goal of prevention strategies is to avoid the occurrence of stroke by educating both healthcare professionals and patients about the reduction of risk factors.

Despite increasing improvements in acute revascularization therapies, preventive measures remain more effective in decreasing the burden of stroke, as evidenced by the fact that over 75 % of strokes are first events. This paper attempts to provide a comprehensive approach by outlining risk factors and new therapeutic approaches. Understanding these is essential for healthcare providers and the general public to develop effective prevention strategies and ultimately reduce the overall incidence of stroke.