New mechanism of vestibular neuritis

Prof. Sun-Uk Lee of the Department of Neurology and Prof. Euyhyun Park of the Department of Otorhinolaryngology from Korea University’s Anam Hospital discovered a new mechanism of vestibular neuritis.

With Prof. Lee and Park, working elaborately as a team (The Neurotology and Neuro-ophthalmology Laboratory of Korea University’s Anam Hospital) recently introduced the association between the anti-GQ1b antibodies and vestibular neuritis.

The research team analyzed 105 patients with vestibular neuritis who had acute dizziness and visited Korea University’s Anam Hospital from 2019 to 2023. 11% of these patients were confirmed antiganglioside antibody positive. Compared those not having these antibodis, bilateral vestibular damage was observed in 33% of the patients with those antibodies. The antibody converted negativealong with improvement of the functional deficits of vestibular nerve.

The fact that autoimmunity plays a role for the development of acute dizziness,may help understand the mechanisms of other various vestibular disorders, too. We anticipate that this research may be a future springboard for immunotherapy in patients presenting with acute vestibular syndrome.
The research team explained
Acute dizziness causes great discomfort to patients and is also difficult to properly be diagnosed, depleting many resources for both patients and society. We hope our research may help patients suffering from dizziness. As the association being confirmed clinically, follow-up research will be conducted how to incorporate these results into treatment.
Prof. Sun-Uk Lee, the leading author of this research

This research was published in Neurology, the most prestigious American academic journal in the field of clinical neurology, and attracting attention from academia under the title of “Clinical features and neurotological findings in patients with acute unilateral peripheral vestibulopathy associated with antiganglioside antibody.”


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