Brain regions related to smell show decline following mild COVID-19

The findings, published in Nature, reveal tissue damage and greater shrinkage in brain areas related to smell. This new insight into the damaging effects of COVID-19 will contribute to our overall understanding of how the disease spreads through the central nervous system. Whether these effects persist in the long term, or are partially reversed, requires further investigation.

The study, led by the Wellcome Centre for Integrative Neuroimaging at the University of Oxford, identified a number of effects, on average 4.5 months following infection, including a greater reduction in grey matter thickness in the regions of the brain associated with smell (the orbitofrontal cortex and parahippocampal gyrus). UK Biobank participants who had COVID-19 also displayed evidence of greater tissue damage in regions connected with the primary olfactory cortex, an area linked to smell, and a reduction in whole brain size. These effects ranged from 0.2 to 2% additional change compared with the participants who had not been infected.

Using the UK Biobank resource, we were in a unique position to look at changes that took place in the brain following mild—as opposed to more moderate or severe—SARS-CoV-2 infection. Despite the infection being mild for 96% of our participants, we saw a greater loss of grey matter volume, and greater tissue damage in the infected participants, on average 4.5 months after infection. They also showed greater decline in their mental abilities to perform complex tasks, and this mental worsening was partly related to these brain abnormalities. All these negative effects were more marked at older ages. A key question for future brain imaging studies is to see if this brain tissue damage resolves over the longer term.

Professor Gwenaëlle Douaud, lead author on the study

Another strength of this study is that it investigated the same people at two different times. Importantly here, the first scan of UK Biobank participants was obtained before they became infected with SARS-CoV-2, and the second scan after infection. The fact that we have the pre-infection scan helps us distinguish brain changes related to the infection from differences that may have pre-existed in their brains.

Professor Stephen Smith, senior author on the study, also from the Wellcome Centre for Integrative Neuroimaging

The UK Biobank COVID-19 Repeat Imaging study is the only study in the world to be able to demonstrate “before vs after” changes in the brain associated with SARS-CoV-2 infection. Collecting a second set of multi-organ imaging scans from some people who had been infected with SARS-CoV-2 and from others who had not been infected has generated a unique resource to enable scientists to understand how the virus affects internal organs. We are incredibly grateful to all of the UK Biobank participants for taking the time to be imaged more than once, to enable researchers to gain valuable insights into long term health effects of SARS-CoV-2 infection.

Professor Naomi Allen, Chief Scientist at UK Biobank

These findings may be the hallmarks of the degenerative spread of COVID-19, either via pathways related to the sense of smell, inflammation or immune response of the nervous system, or a lack of sensory input owing to a loss of smell. The future vulnerability of the brain regions affected in these participants requires further investigation.

The paper ‘SARS-CoV-2 is associated with changes in brain structure in UK Biobank’ by Douaud et al. can be read in Nature.

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