Journal of the Neurological Sciences issue 432 now available

Review Article

Clinical milestones in Parkinson's disease: Past, present, and future

• Disease milestones represent clinically relevant measures of disease progression.
• A score of 3 or more on Hoehn and Yahr scale is the most common motor milestone.
• Clinical milestones have expanded to include motor and non-motor manifestations, and functionality.
• Milestones should be periodically assessed in the care of every affected individual.
• Milestones could inform on disease-modifying interventions.

Full Length Article

Clot evaluation and distal embolization risk during mechanical thrombectomy in anterior circulation stroke

Clot features along with patients' clinical features may influence thrombus compactness predisposing at distal embolization during thrombectomy. The aim of this study was to evaluate thrombus features assessed by radiological and histopathological analysis along with patient-related features to predict distal embolization during thrombectomy.

The combined effect of anticoagulant therapy and thrombus length may have a potentially harmful effect on reperfusion during mechanical recanalization, causing distal embolization and this aspect should be taken into account in patient's risk assessment and when planning treatment strategy.

Research paper

Characteristics of myotonic dystrophy patients in the national registry of Japan

Myotonic dystrophies (DM) are inherited autosomal dominant disorders affecting multiple organs. Currently available therapeutics for DM are limited; therefore, a patient registry is essential for therapeutic development and success of clinical trials targeting the diseases.

We have developed a nationwide DM registry in Japan under the Registry of Muscular Dystrophy (Remudy).

This report will shed light on the Japanese national DM registry, which has recruited a significant number of patients. The registry will provide invaluable data for planning clinical trials and improving the standard of care for patients.

Full Length Article [FREE]

Neurologic and cognitive sequelae after SARS-CoV2 infection: Different impairment for ICU patients

The exact incidence of neurological and cognitive sequelae of COVID-19 in the long term is yet unknown. The aim of this research is to investigate the type of neurological and cognitive impairment in COVID-19 cases of different severity.

Obtained results support the greater susceptibility of COVID-19 patients, treated in ICU, to develop neurological deficits and cognitive impairment at a four-month follow up, as compared to cases with mild/moderate symptoms.