WFN Publications: Featured Articles

Editors' Choice

Links to important articles and articles of particular interest chosen by the Editors
published in last 3 months in Journal of the Neurological Sciences, World Neurology and eNeurologicalSci.


World Neurology: January-February 2024, Volume 39, No. 1


  • By Cassandra Kniffin Arnold and Joanna Amberger

    In 1863, Nikolaus Friedreich described a juvenile-onset form of hereditary ataxia (Friedreich ataxia). Several years later, George Huntington described an adult-onset hereditary chorea (Huntington disease). Nearly 100 years later, these familial genetic neurologic disorders, along with over 1,400 other genetic disorders, were included in Dr. Victor McKusick's seminal textbook Mendelian Inheritance in Man: Catalogs of Autosomal Dominant, Autosomal Recessive, and X-linked Phenotypes (MIM).


  • Placebo/Nocebo and the Brain
    By Fabrizio Benedetti

    Modern medicine and neurology have progressed in parallel with the advancement of biochemistry, anatomy, and physiology. By using the tools of modern medicine and neurology, today the physician and the neurologist can treat and prevent a number of diseases through pharmacology, genetics, and physical interventions, including surgery. In addition to this materia medica, the patient's mind, cognitions and emotions play a central part as well in any therapeutic outcome. Placebo effects are at the very heart of these issues and, maybe paradoxically, they can be approached by using the same biochemical, cellular, and physiological tools of the materia medica, which represents an epochal transition from general concepts such as suggestibility and power of mind to a true physiology and biology.


Journal of the Neurological Sciences

  • The effect of asymptomatic intracranial hemorrhage after mechanical thrombectomy on clinical outcome ⧉

    Suzuki K, Katano T, Numao S, Nishi Y, Kutsuna A, Kanamaru T, Saito T, Aoki J, Nishiyama Y, Kimura K.

    Journal of the Neurological Sciences. 2024 Feb 15;457:122868.

    Whether asymptomatic intracranial hemorrhage (ICH) affects the clinical outcomes in patients with acute large vessel occlusion treated with mechanical thrombectomy (MT) remains unclear. This study aimed to address this uncertainty.


  • Asymptomatic or agnostic? Precision medicine of hemorrhagic transformation after endovascular therapy ⧉

    Liebeskind DS. 

    Journal of the Neurological Sciences. 2024 Jan 24.

    Hemorrhagic transformation (HT) in acute ischemic stroke (AIS) may evolve due to initial ischemia or subsequent reperfusion that occurs spontaneously, or in association with intravenous thrombolysis (IVT) or endovascular thrombectomy (EVT). HT is the most common safety concern in therapeutic revascularization with either IVT or EVT.

    It is increasingly clear that our current definitions of HT require an update in 2024. Revision of HT terminology and methodology should reflect the underlying data of such hemorrhages, aligning with the precision medicine of individual patient stroke diagnoses based on initial NIHSS score, ischemic severity on imaging, location of arterial occlusion and collateral status, and corresponding response to therapies such as IVT or EVT, including the impact of revascularization and concomitant vascular complications.


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eNeurologicalSci (eNS)



    Qaryouti D, Jibril O, Silva FD, Jain P, Gangu K, Sheikh AB.

    Eneurologicalsci. 2023 Dec 1;33:100476.

    Although female representation has been growing among physicians, women continue to be underrepresented in neurology, particularly regarding academic research in authorship and leadership. Analyzing recent trends in high-impact neurology journals highlights the underrepresentation of women and helps explore barriers to female representation in academic neurology.

    Women are significantly under-represented in the field of neurological research in leadership positions as editor-in-chiefs, editorial board members as well as first or senior authors in top neurology medical journals. With continued underrepresentation of women occupying leading publishing roles, parity with men is still a work in progress. Additional work is needed to identify and address barriers to academic advancement for women physicians in academic neurology.


    Th C, Dicko OA, Sangaré M, Sissoko AS, Cissé L, Landouré G, Djimdé SO, Yalcouyé A, Coulibaly T, Karambé M, Maiga YM.

    Eneurologicalsci. 2023 Sep 26:100477.

    Epilepsy is a significant public health concern with psychosocial impacts, including fear, stigma, and misconceptions. These factors contribute to human rights violations and discrimination. The objective of this study was to describe the sociocultural representation of epilepsy in Mali.

    This cross-sectional descriptive study was carried out from April 2015 to November 2016 at the University Hospital of Point G. Patients with epilepsy were identified prospectively, and a questionnaire was administered to each patient and their parents.

    The sociocultural perception of epilepsy hinders evidence-based diagnosis and management in Africa. This study suggests a need to focus on raising awareness to change these misconceptions.


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