The April issue of the Journal of the Neurological Sciences Vol 484
Issue highlights
Review Article
AQP4 levels in CSF correlate with clinical severity in iNPH patients: A pilot studyBelgrado et al.Published online: January 20, 2026
This study investigates cerebrospinal fluid biomarkers in Idiopathic Normal Pressure Hydrocephalus, focusing on the roles of aquaporin-1 (AQP1) and aquaporin-4 (AQP4) in glymphatic function. Researchers found that AQP1 levels were significantly higher in iNPH patients compared to controls, suggesting a potential diagnostic role, while AQP4 levels correlated with the severity of motor and cognitive symptoms. These findings highlight distinct biomarker patterns linked to disease mechanisms and clinical presentation. |
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Research Article
Evaluating in-person clinician versus patient-reported modified Rankin Scale scores among adults with stroke in ZambiaNair et al.Published online: February 19, 2026
This study examines discrepancies between clinician-assessed and patient-reported outcomes using the modified Rankin Scale in stroke patients in Zambia. Findings showed only moderate agreement, with scores matching in about half of cases. Differences were driven by factors such as translation challenges, caregiver input, fear of performing physical tasks, and varying interpretations of disability, particularly for non-motor symptoms. These results highlight the influence of cultural and contextual factors on outcome assessment. |
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Research Article
The efficacy and safety of intra-arterial tenecteplase after recanalization in ischemic stroke: A systematic review and meta-analysis with trial sequential analysis and GRADE assessmentShaban et al.Published online: March 4, 2026
This study evaluates the use of intra-arterial tenecteplase as an adjunct therapy following endovascular thrombectomy in patients with Acute Ischemic Stroke caused by large vessel occlusion. The analysis found that adding tenecteplase after successful recanalisation improved functional outcomes, with more patients achieving excellent recovery scores, without increasing the risk of intracranial haemorrhage or mortality. These findings suggest a potential strategy to address microvascular failure and reduce futile recanalisation after thrombectomy. |
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Research Article | Open Access
Are there disparities in cerebral sinus venous thrombosis between the Arab and Jewish populations in Israel - a multicenter cohort study?on behalf of the Israeli CSVT ConsortiumPublished online: February 27, 2026
This study examines ethnic differences in Cerebral Venous Sinus Thrombosis using data from the Israeli CSVT cohort. Arab patients were younger, more often male, and had higher rates of conditions such as Behçet’s disease and coagulopathies, while differences were also seen in clinical presentation and lower recanalisation rates compared to Jewish patients. Despite these variations, overall outcomes, including mortality and recurrence, were similar between groups. |
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