Journal of the Neurological Sciences issue 482 now available

Analysis of prognostic factors in acute encephalopathy with biphasic seizures and late reduced diffusion: a retrospective study on MRI findings and the treatments

Published online: January 20, 2026

A retrospective study examines prognostic factors in acute encephalopathy with biphasic seizures and late reduced diffusion (AESD), analysing short- and long-term neurological outcomes in affected children.

The study found that extensive MRI lesions were strongly associated with poorer short-term outcomes, while edaravone treatment was linked to improved long-term prognosis.

Read the full article for insight into key imaging and treatment-related predictors in AESD.

Futile recanalisation in patients with anterior large vessel occlusion stroke randomised to mechanical thrombectomy

Published online: January 26, 2026

A secondary analysis of the MR CLEAN trial investigates why many patients with large vessel occlusion (LVO) stroke experience futile recanalisation (FR) despite successful mechanical thrombectomy (MT). The study examines patient factors linked to treatment response, vessel recanalisation, and 3-month functional outcomes. The findings suggest that different predictors influence technical and clinical success. Shorter onset-to-groin time was associated with successful recanalisation, while higher age and poorer collateral status were linked to futile recanalisation. Sex differences also influenced outcomes, with certain factors showing predictive value for FR.

Read the full article for a deeper look at how patient characteristics may help predict treatment response and guide decision-making in mechanical thrombectomy.

Opisthotonus: Revisiting a classic movement disorder

Published online: January 29, 2026

A clinical review examines the causes of opisthotonus—a severe backward arching of the trunk caused by involuntary contraction of paraspinal muscles—drawing on data from over 1,200 patients assessed at a tertiary movement disorders centre. Among identified cases, functional movement disorders were the most common cause, followed by various forms of dystonia and structural or hypoxic brain injury. The study emphasises the importance of determining the underlying aetiology, particularly in infants where metabolic or genetic causes may be involved, as management strategies differ significantly.

Read the full article for a detailed overview of diagnostic considerations and current therapeutic approaches for opisthotonus, including pharmacological and surgical options.

OSA Treatment Lowers the Risk of Declining Daily Activities

Published online: February 2, 2026

A seven-year follow-up study explored whether severe obstructive sleep apnoea (OSA) affects quality of life, fatigue, and functional ability after ischaemic stroke. Among 136 survivors, those with severe OSA (REI ≥30/h) had poorer mobility, lower functional scores, and greater need for medical aids. Overall quality of life remained good but tended to be lower in patients with severe OSA. Continuous positive airway pressure (CPAP) treatment was associated with better ability to perform usual activities, while higher BMI independently predicted reduced quality of life.

Read the full article for detailed long-term outcome data and clinical implications.