The November issue of the Journal of the Neurological Sciences Vol 478
Issue highlights
Research Article
The expanding clinical utility of blood neurofilament light chain (bNfL): a multi-disciplinary diagnostic toolKörtvelyessy et al.Published online: August 22, 2025
The protein neurofilament light chain in blood (bNfL) has become a valuable biomarker in the diagnosis, monitoring, and prognosis of neurological diseases. However, its potential use beyond neurology in routine clinical practice remains unexplored. This study aimed to examine the clinical utility of bNfL by investigating its expanding use (i) assessing its integration into in- and outpatient routine practice, (ii) both within and outside of academic hospitals, and (iii) across different medical disciplines and various departments... |
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Research Article
Genetic and clinical profile of a Brazilian cohort of dopa-responsive dystoniade Alencar Guerra et al.Published online: August 29, 2025
Twenty-two patients were recruited from the SARAH Network of Rehabilitation Hospitals. A retrospective analysis of phenotype-genotype correlation from the next generation sequencing (NGS) genetic test alongside clinical features and evolution were performed. Clinical measures included: age at the disease onset, gender, time of diagnosis, response to Levodopa medication, behavioral symptoms related to psychiatric disorders. .. |
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Research Article
Electronic health record analysis reveals no association between COVID-19 vaccines and ischemic strokeMakkar et al.Published online: August 29, 2025
Using data from the National COVID Cohort Collaborative (N3C) database, we identified 119,275 patients (n = 39,922 vaccinated, n = 79,353 unvaccinated) who were at least 16 years of age and suffered ischemic stroke between February 2021 and April 2023. We applied the Self-Controlled Case Series (SCCS) to estimate the association between multiple vaccine-type-dose combinations and risk of incident ischemic stroke. We calculated incident rate ratios (IRRs) to compare incidence of ischemic stroke during the 28-day risk period following vaccine or SARS-CoV-2 exposure versus baseline periods of no vaccine exposure. Because patients who experience strokes are unlikely to receive the first or subsequent vaccinations, we applied SCCS methods capable of handling such event-dependent exposure to ensure valid results...
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Research Article | Open Access
Low synaptic and neurosecretory proteins in cerebrospinal fluid in early parkinsonian diseaseJakobsson et al.Published online: September 4, 2025
The early pathogenesis of Parkinson's disease (PD) and the atypical parkinsonian disorders multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) is poorly understood, but presynaptic and axonal dysfunction are hypothesized to play a prominent role... |
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