Author: Zuo Y, Ding X, Sun Y, Wang L, Song Y, Zhao Z, Liu C.
Editor's Choice
Journal of the Neurological Sciences | Critical nodes in precision diagnosis and treatment of Alzheimer's disease: exploration of multidimensional biomarkers and prospects for targeted intervention
Article Link: https://www.jns-journal.com/article/S0022-510X(25)00354-5
A new review explores how advances in Alzheimer's disease (AD) research are linking core disease mechanisms with emerging biomarker strategies. The article focuses on key pathological processes such as β-amyloid accumulation, Tau hyperphosphorylation, neuroinflammation, and mitochondrial dysfunction as central targets for therapy.
It highlights recent progress in liquid, imaging, and multi-omics biomarkers, emphasising their potential for earlier diagnosis, disease stratification, and treatment monitoring. The review also discusses how combining therapeutic targets with biomarker profiles could support more personalised approaches to AD care, while outlining ongoing challenges such as disease heterogeneity and limited biomarker sensitivity.
Read the full article for a concise overview of how integrated biomarkers and therapeutic targets are shaping the future of precision medicine in Alzheimer's disease.
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