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World Neurology


  • Cerebral Venous Thrombosis After Vaccination Against SARS-CoV-2 ⧉

    With Information on the International Consortium on CVT Registry By José M. Ferro, MD, PhD.

    The public and the global medical community have been exposed since early March 2021, both from the media, the official agencies, and the medical literature, to multiple and often contradictory information, concerning the risk of "uncommon" thrombosis occurring after vaccination against SARS-CoV-2.

  • Tabes Dorsalis and the Romberg Test; Historical Aspects ⧉

    As probably most neurologists will know, general paralysis of the insane (GPI, also known as general paresis and dementia paralytica) and tabes dorsalis are the two main neurological manifestations of late neurosyphilis. The first condition was recently discussed by Fiolet and Daey Ouwens in an article on malaria fever therapy and has become relatively rare. (See World Neurology October/November 2020.) The latter disease became very rare during the past decades, and only few living neurologists will ever have observed it.

    In a time that it was much more frequent, a neurological test became associated with it, notably the Romberg Test. It was introduced in a period that this eponymist will not have realized that it was a syphilitic disease.


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Journal of the Neurological Sciences


  • A prospective study of long-term outcomes among hospitalized COVID-19 patients with and without neurological complications ⧉

    Little is known regarding long-term outcomes of patients hospitalized with COVID-19.

    In this prospective study, it was found that patients diagnosed with new neurological complications during hospitalization for COVID-19 had a 2-fold increased odds of worse 6-month functional outcome (as measured by the modified Rankin Score) compared to hospitalized COVID-19 patients without neurological complications.

    Over half of these neurologically affected patients could not independently perform some of their basic activities of daily living and 59% of those employed prior to COVID-19 infection were unable to return to work by 6-months.

  • Characteristics and outcomes of 100 consecutive patients with acute stroke and COVID-19 ⧉

    The coronavirus disease 2019 (COVID-19) pandemic started as a respiratory illness. Now, there are increasing reports of its hypercoagulable and thrombotic complications leading to stroke. Initial studies suggested strokes to be a feature of severe and late COVID-19; usually occurring in the second week of illness after the onset of typical respiratory symptom .

    This retrospective, multi centre observational study, presenting a large cohort of 100 consecutive patients with COVID-19 and acute strokes, is an epidemiological representation of the association of COVID-19 and stroke from Mumbai as the data is pooled from 10 different centres across the city which was worst affected during the height of the pandemic.


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eNeurologicalSci (eNS)


  • Management dilemmas in acute ischemic stroke and concomitant acute pulmonary embolism: Case series and literature review ⧉

    Pulmonary embolism (PE) and acute ischemic stroke (AIS) are common disorders with high morbidity and mortality, rarely presenting simultaneously, and there is a paucity of data regarding the management of this uncommon presentation. The treatment of these two entities is complex in the acute phase due to the concomitant need for thrombolysis in AIS and anticoagulation for PE.

    In a retrospective review of patients with confirmed ischemic stroke cases and simultaneous PE, as well as a literature review, intravenous anticoagulation (70.5%) was the most frequent intervention targeting both disorders.

    According to the review, the ischemic stroke burden guides systemic anticoagulation decisions over interventional procedures when the hemodynamic status remains unaffected.

  • Voxel-based correlation of 18F-THK5351 accumulation with gray matter structural networks in cognitively normal older adults ⧉

    The aim of this study was to evaluate tau-related structural network metrics derived from grey matter magnetic resonance imaging (MRI) scans in cognitively normal (CN) older adults.

    Significant positive correlations of the four local network metrics with 18F-THK5351 were detected in the bilateral caudate.

    The findings suggest that tau and neuroinflammation in CN older adults may influence the gryy matter structural network in the caudate.



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