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By Dr. Yousef Patel
Supported by global partners such as the World Federation of Neurology and the American Academy of Neurology, the course emphasized its theme, “Neurology Without Borders,” highlighting the shared continental responsibility to advance brain health in Africa through collaboration, ethical practice, skills development, and strong regional networks.
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By Prof. Massimo Leone
Sub-Saharan Africa has 1.3 billion inhabitants. The estimated number of PLWE in the region exceeds 20 million, but there is only one neurologist for every 2 million people.
The majority of PLWE in Sub-Saharan Africa are managed in primary care facilities by nonphysician clinicians (NPCs) whose education on the disease is insufficient. More than 75% of PLWE have little or no access to treatment. The Sub-Saharan African population is expected to double by 2050, as is the number of PLWE.
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By Ndonji Chiwaya
Educators in Zambia decided to challenge the status quo with a fresh approach: the flipped classroom model. No more marathon lectures with passive note-taking. Instead, students viewed neurology content before class via prerecorded online video lectures. They then spent valuable class time participating in interactive, small-group discussions focused on real clinical cases...
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By Dr. Aida Suárez-Gonzalez, Prof. Morris Freedman, Dr. Thomas Bak, Prof. Adesola Ogunniyi, Prof. Gladys E. Maestre, and Prof. Raj Kalaria
Dementia and Brain Aging in Low- and Middle-Income Countries, a symposium held Dec. 3-6, 2024, in Nairobi, Kenya, marked another milestone in global efforts to advance equitable brain health. Hosted at the Safari Park Hotel, the event brought together more than 200 delegates from Africa and the world, representing a wide spectrum of researchers, clinicians, and policymakers. The setting underscored the meeting's purpose: to center the voices, knowledge, and experiences of those working within low- and middle-income countries (LMICs), where the burden of dementia is growing rapidly...
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By Dr. Chandrashekhar Meshram
The Orange City Cultural Foundation (OCCF), in collaboration with the P.M. Shah Foundation, Nagpur Municipal Corporation, Rashtrasant Tukadoji Maharaj Nagpur University, CineMontage, and Saptak Napur, organized the Orange City Aarogya Film Festival on March 29-30, 2025, in Nagpur, India.
This initiative, a brainchild of Dr. Chandrashekhar Meshram, president of the OCCF and trustee of the World Federation of Neurology (WFN), was the first health-focused film festival in central India. The idea was to create health awareness in the general public and inspire people to do good work on health-related issues...
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Handelsmann HL, Herzog L, Hoving AJ, Majoie C, Van Zwam W, Van der Lugt A, Wegener S, MR CLEAN Investigators.
Up to half of patients with large vessel occlusion (LVO) stroke experience futile recanalisation (FR) despite successful mechanical thrombectomy (MT). In a retrospective analysis of the MR CLEAN cohort (n=461), predictors of treatment response, vessel recanalisation, and FR were examined.
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Abdullah A, Malik T, Shuja H, Bashir M, Wamiq U, Ibrahim HY, Aamir MS.
Glioblastoma multiforme remains the deadliest primary brain tumor, largely due to its ability to evade the immune defenses of the central nervous system. This review highlights how GBM exploits mechanisms such as MHC downregulation, immunosuppressive cytokine secretion, metabolic reprogramming, and recruitment of Tregs and myeloid-derived suppressor cells, reinforced by tumor heterogeneity and the blood–tumor barrier.
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Nakase T, Takano Y, Nomura S, Baek HW, Takayama S, Ono R, Abe M, Ishii T, Tatewaki Y, Taki Y.
This study explores the neurological mechanisms behind “brain fog” and other cognitive symptoms associated with Long COVID by analysing brain imaging and blood biomarkers in affected patients. Using MRI, cerebral blood flow imaging, and a range of neuropsychological tests, researchers identified associations between cognitive performance, anxiety and depression scores, and changes in blood flow in specific brain regions, particularly the occipital and parietal lobes.
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Pupillo E, Leone MA, Amato A, Bianchi E, Damian MS, Dyck J, Garcia-Azorin D, Giussani G, Guekht A, Koike H, Khadilkar S.
This systematic review and meta-analysis aimed to determine the long-term prevalence in COVID-19 survivors of fourteen specific NMDs and related symptoms: cranial nerve diseases, Guillain-Barré syndrome, small fiber neuropathy, (poly)radiculopathies, (poly)neuropathies, plexopathies, motor neuron disease, myasthenia gravis, Lambert-Eaton syndrome, neuropathic pain, sarcopenia, myalgia, myalgia associated with other symptoms, and of other muscle diseases.
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Handelsmann HL, Herzog L, Hoving AJ, Majoie C, Van Zwam W, Van der Lugt A, Wegener S, MR CLEAN Investigators.
Journal of the Neurological Sciences. 2026 Jan 26:125772.
Up to half of patients with large vessel occlusion (LVO) stroke experience futile recanalisation (FR) despite successful mechanical thrombectomy (MT). In a retrospective analysis of the MR CLEAN cohort (n=461), predictors of treatment response, vessel recanalisation, and FR were examined.
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Messak M, Abdelmageed A, Khattab YA, Altalab G, Mandour Y, Shaker O.
Journal of the Neurological Sciences. 2026 Feb 10:125806.
A new review evaluates why monoclonal antibodies (mAbs) targeting α-synuclein have so far failed to demonstrate clinical benefit in Parkinson's disease (PD), despite strong preclinical promise. Analysing data from five randomised controlled trials, the authors assess safety, pharmacokinetics, central nervous system exposure, and target engagement.
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OPEN ACCESS JOURNAL
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Saleem S, Kamal AK, Aziz N, Hasan S, Khan AS, Mubarak F, Shakeel E, Durrani R, Qamar S, Sattar S, Asghar S.
eNeurologicalSci. 2026 Feb 27:100606.
This study evaluated a high-fidelity simulation training program for hyperacute Stroke management among healthcare professionals in Pakistan, conducted at Aga Khan University. The course significantly improved participants’ confidence and performance in stroke triage, communication, clinical assessment, and treatment decision-making. Findings also highlighted systemic challenges such as the absence of standardized stroke pathways and workflow delays, reinforcing the value of structured, team-based simulation training in improving acute stroke care.
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Kaindl L, Hotz JF, Ferrari J.
eNeurologicalSci. 2025 Jun 1;39:100561.
Stroke represents a major public health problem, ranking as a leading cause of death and long-term disability worldwide. The goal of prevention strategies is to avoid the occurrence of stroke by educating both healthcare professionals and patients about the reduction of risk factors.
Despite increasing improvements in acute revascularization therapies, preventive measures remain more effective in decreasing the burden of stroke, as evidenced by the fact that over 75 % of strokes are first events. This paper attempts to provide a comprehensive approach by outlining risk factors and new therapeutic approaches. Understanding these is essential for healthcare providers and the general public to develop effective prevention strategies and ultimately reduce the overall incidence of stroke.
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Aka KC, Nancy ED, Muriel AT, Cedric AP, Delors OF, Arlette AD, David B, Axel TB, Constance YE, Christian T, Evelyne AD.
eNeurologicalSci. 2025 Apr 15:100566
This was a prospective cross-sectional study carried out during the 2022–2023 academic year at the Abidjan UFR of Medical Sciences. The study population consisted of all students in years 3ème to 6ème and hospital interns. The Schon questionnaire, transcribed using google form software, was sent to students using the "whatsapp" social network.
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Grisold W, Lewis SL.
eNeurologicalSci. 2025 Jan 5;38:100548
Congresses remain the main source of scientific meetings, combining science and education as well as personal interactions. Congresses are slowly returning to in-person meetings; however, some organizations, such as the World Federation of Neurology (WFN), adhere to the hybrid concept, both virtual and in-person.
To do this, we host the WFN World Congresses of Neurology (WCN), which reports the latest achievements and will remain hybrid (https://wcn-neurology.com); however, we think that two years between congresses is too long. For this reason, we introduced the World Federation of Neurology Digital Neurology Update (WNU)
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Crivelli L, Winkler A, Keller G, Beretta S, Calandri I, De Groote W, Fornari A, Frontera J, Kivipelto M, Lopez-Rocha AS, Mangialasche F.
eNeurologicalSci. 2024 Nov 21:100539
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