JNS.jpgThe January issue of the Journal of the Neurological Sciences Vol 421 is now available online.


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Issue highlights

Physical restraint precipitates delirium in stroke patients

In this issue of Journal of the Neurological Sciences, an interesting paper by Nakamizo and colleagues analyses causative effect of uncomfortable care on delirium onset in stroke patients.

Assessing neurophobia: A good move

Recently, medical education has been considered an emerging subspeciality within neurology.. Teaching is an exciting and rewarding activity, especially in such an interesting field. However, medical educators in neurology face a specific challenge: neurophobia.

Inclusion of ethnoracial populations and diversity remains a key challenge in Alzheimer's disease biofluid-based biomarker studies

Along with a rapidly growing population of older adults, Alzheimer's disease and related dementia (ADRD) are prevalent worldwide (50 million in 2020) and will continue to increase (152 million in 2050) in subsequent decades.

Low-and-middle-income countries will see more than two-thirds of dementia cases and added burden by 2050. These growths will also be accompanied by more racial and ethnic diversity among adults worldwide.

Alzheimer's disease (AD) alone accounts for 60–80% of dementia cases—a significantly higher risk for ADRD has been reported for Blacks/African Americans and Hispanics/Latinos when compared to non-Hispanic Whites

Comparing fluid biomarkers of Alzheimer's disease between African American or Black African and white groups: A systematic review and meta-analysis

Biomarker research for Alzheimer's disease (AD) has grown rapidly in recent years, ensuing the integration of the AD fluid biomarker profile: Aβ1-42, t-tau, and p-tau 181, into clinical and research criteria. However, current insights of AD arise almost exclusively from studies on white individuals. Some studies have revealed that epidemiology, clinical features, and genetics of AD show variations between individuals from black and white backgrounds, conveying the importance of ethnoracial differences, and the possibility of such differences also influencing AD biomarker levels. This systematic review explored whether AD fluid biomarker levels differ between African American (AA) or Black African and white groups.

  • Epidemiology and clinical/genetic aspects of AD vary between African Americans (AA) and whites.
  • A systematic review and meta-analysis were performed to compare CSF Aβ and tau between AA and whites.
  • The meta-analysis found CSF t-tau and p-tau181 were significantly lower in AA than white individuals.