A systematic understanding of the burden of neurological disorders at the subnational level is not readily available for India. This study presents a comprehensive analysis of the disease burden and trends of neurological disorders at the state level in India.

With an ageing population globally, the burden of neurological disorders is rapidly increasing, posing a challenge to the sustainability of health systems, including in low-income and middle-income countries. The burden of neurological disorders is also expected to increase in India due to the rapid demographic and epidemiological transition occurring in the country.

Evidence regarding the incidence, prevalence, and disease burden associated with neurological disorders in India is scarce. Only a few local studies have reported disease burden for some neurological disorders.We have previously reported the state-level distributions of stroke and brain and nervous system cancers. However, a recent and comprehensive understanding of the magnitude and trends of all neurological disorders is not available, which is required for evidence-based preventive strategies, health-care planning, priority setting, and resource allocation.

In 2020, the 73rd World Health Assembly resolution on global actions on epilepsy and other neurological disorders called for a globally integrated strategy underpinned by preventive, diagnostic, therapeutic, and rehabilitative plans to address neurological conditions more effectively in low-income and middle-income countries.

Using all accessible data from multiple sources, we estimated the prevalence or incidence and disability-adjusted life-years (DALYs) for neurological disorders from 1990 to 2019 for all states of India as part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019. We assessed the contribution of each neurological disorder to deaths and DALYs in India in 2019, their trends in prevalence or incidence and DALY rates over time, and heterogeneity between the states of India. We also assessed the Pearson correlation coefficient between Socio-demographic Index (SDI) of the states and the prevalence or incidence and DALY rates of each neurological disorder. Additionally, we estimated the contribution of known risk factors to DALYs from neurological disorders. We calculated 95% uncertainty intervals (UIs) for the mean estimates.


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    The Global Burden of Disease study provides the most comprehensive global health estimates, examining worldwide, national, and regional trends for mortality and morbidity from major diseases, injuries, and risk factors to understand the health challenges of the 21st century.

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