JNS.jpgThe November issue of the Journal of the Neurological Sciences Vol 406 is now available online.


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Issue highlights

Cerebral amyloid angiopathy-related transient focal neurological episodes (CAA-TFNEs): A well-defined clinical-radiological syndrome

Cerebral amyloid angiopathy (CAA), is a common degenerative small vessel disease of the ageing brain resulting from progressive amyloid deposition, predominantly in small arteries and arterioles of the cortex and leptomeninges. CAA is more relevant than ever since it can now be readily diagnosed during life using validated neuroimaging criteria (aka the Boston criteria), particularly with the widespread use of blood-sensitive T2* MRI sequences. Consequently, the dominant theme of CAA-related clinical research and practice in the last decade or so has been the growing appreciation of the diverse manifestations of the disease.

Myasthenia gravis: Historical achievements and the "golden age" of clinical trials



Since the death of Chief Opechankanough >350 years ago, the myasthenia gravis (MG) community has gained extensive knowledge about MG and how to treat it.

This review highlights key milestones in the history of treatment and discusses the current "golden age" of clinical trials. Although originally thought by many clinicians to be a disorder of hysteria and fluctuating weakness without observable cause, MG is one of the most understood autoimmune neurologic disorders.

Sex differences in risk factors for aneurysmal subarachnoid haemorrhage: Systematic review and meta-analysis

Aneurysmal subarachnoid haemorrhage (aSAH) disproportionally affects women. Here, a systematic review and meta-analysis to explore sex differences in aSAH risk factors are conducted.

  • In both sexes, smoking, blood pressure, family history and age increased aSAH risk.
  • Fluctuations in reproductive hormones appear as an important risk for aSAH in women.
  • Re-analyses of existing studies of aSAH risk factors considering sex differences.
  • Management of known risk factors for aSAH should be the focus of preventing aSAH.


Neutrophil to lymphocyte ratio predicts poor outcomes after acute ischemic stroke: A cohort study and systematic review

The relationship between neutrophil to lymphocyte ratio (NLR) and prognosis after acute ischemic stroke (AIS) remains controversial. The aim of this cohort study and systematic review was to ascertain the association of admission NLR with major clinical poor outcomes after AIS.

  • Patients with poor outcome after stroke had higher neutrophil to lymphocyte ratio.
  • Neutrophil to lymphocyte ratio >5 increased the risk of poor prognosis.
  • Neutrophil to lymphocyte ratio was associated with haemorrhage after ischemic stroke.
  • Higher neutrophil-lymphocyte ratio was independently associated with 3-month death.
  • Neutrophil to lymphocyte ratio had the highest predictive accuracy for 3-month death.