By Tissa Wijeratne, David Dodick, Wolfgang Grisold, William Carroll

First published: 22 July 2019

iStock 478239274 migraine

Every year, the World Federation of Neurology (WFN) celebrates World Brain Day (WBD) on July 22 (the official anniversary of WFN) with each year focusing on a different theme. This year the theme is " Migraine, The Painful Truth". Migraine is the number one cause of disability affecting people under the age of fifty years (the group with the highest contribution to the worldwide workforce) making it one of the highest negative economic impacts globally.

According to the latest analysis from the Global Burden of Disease (3) study, almost 3 billion people had a headache disorder in 2016, including 1.04 billion with migraine. Unfortunately, despite the prevalence and public health burden, migraine research remains seriously underfunded, the disease and people with migraine and other headache disorders experience substantial stigma, and migraine continues to be under‐diagnosed and poorly managed, especially in developing countries.


The European Journal of Neurology  covers all areas of clinical and basic research in neurology. Emphasis is placed on major diseases of large clinical and socio-economic importance (dementia, stroke, epilepsy, headache, multiple sclerosis, movement disorders, and infectious diseases). In addition to original papers, the journal publishes review and update papers, letters to the editor, book reviews and short reports. Important articles can be fast-tracked. 

This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record.