JNS.jpgThe January issue of the Journal of the Neurological Sciences Vol 396 is now available online.


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Issue highlights

Outcome of human peripheral nerve repair interventions using conduits: a systematic review

  • High quality randomized controlled trials on peripheral nerve injury outcome are scanty
  • Most existing studies with well-characterised intervention and outcome measures are inadequately powered
  • A meta-analysis of three RCTs meeting above criteria with adequate homogeneity were identified
  • Human peripheral nerve repair using conduits for sensory nerves significantly more effective than direct nerve suture
  • Sufficiently powered high-quality RCTs are needed to determine efficacy of conduits on motor and mixed nerve repairs
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Huntington disease: A quarter century of progress since the gene discovery

  • Discovery of the genetic cause for Huntington disease (HD) opened the "gene hunter" era.
  • Discoveries are still being made on phenotype-CAG length relationships, why CAG lengths expand, and age of onset modifiers.
  • Research on non-choreic and non-motor features drives current debate over how to best diagnose clinical and preclinical HD.
  • Symptomatic care focused on function and quality of life can make a significant positive impact at all stages of HD.
  • Novel disease-modifying therapeutics leverage several mechanisms, most prominently huntingtin lowering strategies.

Natalizumab exposure during pregnancy in multiple sclerosis: a systematic review

  • Spontaneous abortion rate in natalizumab exposure subjects varied from 9.4% to 17.4%.
  • Major birth defects rate varied from 2.9% to 5.1% in natalizumab exposure subjects.
  • After natalizumab discontinuation during pregnancy, the relapse rate varied from 21.4% to 36.5%.

Hydrogen as a complementary therapy against ischemic stroke: A review of the evidence

  • We summarized the therapeutic effect and mechanism of hydrogen to ischemic stroke or cerebral I/R injury.
  • Anti-oxidation, anti-inflammation and anti-apoptosis are essential mechanisms of hydrogen.
  • We come up with several new outlooks about the investigation of hydrogen therapy.
  • Hydrogen therapy is an ideal complementary therapy to ischemic stroke.
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