JNS.jpgThe November issue of the Journal of the Neurological Sciences Vol 394 is now available online.


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Issue highlights

Concurrent Guillain-Barré syndrome, transverse myelitis and encephalitis post-Zika: A case report and review of the pathogenic role of multiple arboviral immunity

We review post-infectious and post-vaccination neurological syndromes involving peripheral and central nervous system (CNS) and report an illustrative case of simultaneous occurrence of Guillain-Barré syndrome (GBS), confirmed by nerve conduction velocities, plus MRI-demonstrated transverse myelitis (TM) and acute encephalitis [acute disseminated encephalomyelitis] (ADEM+GBS) affecting a 24-year-old woman from Cúcuta, Colombia, who developed acute Zika virus (ZIKV) infection confirmed by serum reverse transcriptase-polymerase chain reaction (RT-PCR) and convalescent ZIKV IgG antibodies.

From reports in the Caribbean, Central and South America we review 19 cases of ZIKV-associated TM, encephalitis and ADEM occurring after a mean latent period of 10.5 days (range 1–96) post-infection.


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Mitochondrial therapeutic interventions in Alzheimer's disease

The purpose of this review is to provide an overview of mitochondrial dysfunction and its role in late onset Alzheimer's Disease (AD) pathology. We then highlight recent antioxidant and enzymatic treatments used to alleviate mitochondrial dysfunction. Finally, we describe current applications of targeted mitochondrial delivery in the treatment of AD.


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Clinching the cause: A review of foot drop secondary to lumbar degenerative diseases

Foot drop is defined as weakness on dorsiflexion of the foot. The top two most common etiologies for foot drop include lumbar degenerative disease and common peroneal nerve injury.

This review provides "updates" on understanding the lumbar etiologies of foot drop. Since the publication of "Preoperative motor strength and time to surgery are the most important predictors of improvement in foot drop due to degenerative lumbar disease" in the Journal of Neurological Sciences, three cohort studies have been published on spinal causes of foot drop. Classification, clinical features, diagnosis, and pathogenesis that may 'clinch' the cause of foot drop are discussed in the context of these recent publications.

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Parkinson disease: A systemic review of pain sensitivities and its association with clinical pain and response to dopaminergic stimulation

Patients with Parkinson disease (PD) experience hyperalgesia on evoked pain sensitivity testing, although the relationship of this with persistent pain in PD is less certain.

Studies examining this have generated contradictory findings. Further, the role of dopaminergic deficiency as an underlying substrate for hyperalgesia is controversial. We report the results of meta-analyses of the PD pain sensitivity literature in an attempt to answer these questions.

Overall, the results of this systematic review and meta-analysis supports the hypothesis that hyperalgesia contributes to clinical pain in PD, and that the underlying mechanism may be dopaminergically driven.

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