JNS.jpgThe August issue of the Journal of the Neurological Sciences Vol 391 is now available online.


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Issue highlights

Formaldehyde, DNA damage, ALS and related neurodegenerative diseases

Carmel Armon argues that causation of disease can be ascertained by application of classical methods of epidemiological inference, and he draws on information gleaned from experience with familial, sporadic and Western Pacific forms of ALS. He concludes that disease in all cases begins with DNA damage in single neurons, probably Betz cells, from which it spreads through the neuronal network by an undefined mechanism. By analogy, he draws on the methods of John Snow, who identified the source of London's 1854 cholera epidemic and, in the 20th century, on Richard Doll and Bradford Hill's reasoning that linked cigarette smoking to lung cancer.

The move: When neurosciences teach us to better teach neurosciences

Although lecturing has been the predominant mode of instruction since the foundation of universities in Western Europe over most of a millennium ago, the traditional "teaching by telling" approach is now being undermined by the latest neuroscience and educational science data. In a well-designed recent meta-analysis published by Freeman et al. [1], 158 studies of student performance under active learning were compared with 67 studies under traditional lecturing. The results demonstrate that active learning increases both performance and motivation, and decreases failures.

Endovascular treatment of symptomatic vertebral artery stenosis: A systematic review and meta-analysis

  • The management of symptomatic vertebral artery stenosis is controversial
  • We evaluated endovascular treatment plus medical treatment (MT) versus MT alone
  • Four randomized controlled trials were included, which involved 370 participants
  • No clear-cut benefits or harms emerged between the treatment arms Abstract Background

The study aim was to evaluate the safety and efficacy of endovascular treatment (EVT) versus medical treatment (MT) in patients with symptomatic vertebral artery (VA) stenosis.

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Diffusion tensor imaging findings in the multiple sclerosis patients and their relationships to various aspects of disability

  • DTI shows subtle abnormalities in white and grey matter in multiple sclerosis patients.
  • DTI indices correlate with measures of manual dexterity and cognition.
  • An occult damage to the strategic areas of the brain may contribute to disability.

The aim of the study was to assess microstructural changes within strategic brain regions in multiple sclerosis (MS) patients, using diffusion tensor imaging (DTI), with regard to various aspects of disability.

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